The effects of 9-amino-1,2,3,4-tetrahydroacridine (THA) and its fully aromatic analogue 9-aminoacridine (9-AA) on erythrocyte membrane morphology were investigated via scanning electron microscopy. The ghost population was categorized into four distinct classes and alterations in the relative amounts of these populations with drug addition were noted. The samples incubated in 9-AA had a significantly higher (p<0.001) flat, two-dimensional cell population. This shift in morphology may be attributable to the unwinding of spectrin and the subsequent collapse of the membrane.
|Number of pages||5|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Sep 29 1989|
Bibliographical noteFunding Information:
This work was supported, in part, by NSF grant RII-86-10671 (DAB). We acknowledge support of the University of Kentucky Major ResearchI nstrumentation Bond Program in the purchaseo f the equipment usedi n this study (7E-7H23).
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology