Morphological alterations in erythrocyte membranes induced by 9-amino-1,2,3,4-tetrahydroacridine and 9-aminoacridine

Donna A. Palmieri; Robert J. Jacob; D. Allan Butterfield

doi:10.1016/0006-291X(89)91127-3

Morphological alterations in erythrocyte membranes induced by 9-amino-1,2,3,4-tetrahydroacridine and 9-aminoacridine

Donna A. Palmieri, Robert J. Jacob, D. Allan Butterfield

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effects of 9-amino-1,2,3,4-tetrahydroacridine (THA) and its fully aromatic analogue 9-aminoacridine (9-AA) on erythrocyte membrane morphology were investigated via scanning electron microscopy. The ghost population was categorized into four distinct classes and alterations in the relative amounts of these populations with drug addition were noted. The samples incubated in 9-AA had a significantly higher (p<0.001) flat, two-dimensional cell population. This shift in morphology may be attributable to the unwinding of spectrin and the subsequent collapse of the membrane.

Original language	English
Pages (from-to)	1351-1355
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	163
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(89)91127-3
State	Published - Sep 29 1989

Bibliographical note

Funding Information:
This work was supported, in part, by NSF grant RII-86-10671 (DAB). We acknowledge support of the University of Kentucky Major ResearchI nstrumentation Bond Program in the purchaseo f the equipment usedi n this study (7E-7H23).

Funding

This work was supported, in part, by NSF grant RII-86-10671 (DAB). We acknowledge support of the University of Kentucky Major ResearchI nstrumentation Bond Program in the purchaseo f the equipment usedi n this study (7E-7H23).

Funders	Funder number
University of Kentucky Major ResearchI nstrumentation Bond Program	7E-7H23
National Science Foundation (NSF)	RII-86-10671

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(89)91127-3

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title = "Morphological alterations in erythrocyte membranes induced by 9-amino-1,2,3,4-tetrahydroacridine and 9-aminoacridine",

abstract = "The effects of 9-amino-1,2,3,4-tetrahydroacridine (THA) and its fully aromatic analogue 9-aminoacridine (9-AA) on erythrocyte membrane morphology were investigated via scanning electron microscopy. The ghost population was categorized into four distinct classes and alterations in the relative amounts of these populations with drug addition were noted. The samples incubated in 9-AA had a significantly higher (p<0.001) flat, two-dimensional cell population. This shift in morphology may be attributable to the unwinding of spectrin and the subsequent collapse of the membrane.",

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note = "Funding Information: This work was supported, in part, by NSF grant RII-86-10671 (DAB). We acknowledge support of the University of Kentucky Major ResearchI nstrumentation Bond Program in the purchaseo f the equipment usedi n this study (7E-7H23).",

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AU - Palmieri, Donna A.

AU - Jacob, Robert J.

AU - Butterfield, D. Allan

N1 - Funding Information: This work was supported, in part, by NSF grant RII-86-10671 (DAB). We acknowledge support of the University of Kentucky Major ResearchI nstrumentation Bond Program in the purchaseo f the equipment usedi n this study (7E-7H23).

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AB - The effects of 9-amino-1,2,3,4-tetrahydroacridine (THA) and its fully aromatic analogue 9-aminoacridine (9-AA) on erythrocyte membrane morphology were investigated via scanning electron microscopy. The ghost population was categorized into four distinct classes and alterations in the relative amounts of these populations with drug addition were noted. The samples incubated in 9-AA had a significantly higher (p<0.001) flat, two-dimensional cell population. This shift in morphology may be attributable to the unwinding of spectrin and the subsequent collapse of the membrane.

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Morphological alterations in erythrocyte membranes induced by 9-amino-1,2,3,4-tetrahydroacridine and 9-aminoacridine

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

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