Morphological alterations in erythrocyte membranes induced by 9-amino-1,2,3,4-tetrahydroacridine and 9-aminoacridine

Donna A. Palmieri, Robert J. Jacob, D. Allan Butterfield

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The effects of 9-amino-1,2,3,4-tetrahydroacridine (THA) and its fully aromatic analogue 9-aminoacridine (9-AA) on erythrocyte membrane morphology were investigated via scanning electron microscopy. The ghost population was categorized into four distinct classes and alterations in the relative amounts of these populations with drug addition were noted. The samples incubated in 9-AA had a significantly higher (p<0.001) flat, two-dimensional cell population. This shift in morphology may be attributable to the unwinding of spectrin and the subsequent collapse of the membrane.

Original languageEnglish
Pages (from-to)1351-1355
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - Sep 29 1989

Bibliographical note

Funding Information:
This work was supported, in part, by NSF grant RII-86-10671 (DAB). We acknowledge support of the University of Kentucky Major ResearchI nstrumentation Bond Program in the purchaseo f the equipment usedi n this study (7E-7H23).

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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