Morphological effects of transposing a segment of transverse colon into the ileum of the Holtzman rat

W. H.St Clair, C. A. Stahlberg, J. W. Osborne

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


In order to determine if the rat colon is capable of adaptation when placed in another location within the intestinal tract and/or subject to different luminal contents, a 3 cm segment of transverse colon was transposed into the ileum. Sixteen days later, the animals were injected with tritiated thymidine (1 μCi/g body weight) and killed one hour later. Autoradiographs were analyzed for number of cells per crypt column, number of labeled cells per crypt column, position of labeled cells in the crypt column, and formation of Paneth cells or villi in the transposed colon. Proliferative activity of the epithelium was measured by isolating whole crypts and determining disintegrations per minute per crypt. Except for alterations in the positions of labeled cells, as determined by crypt profiles, no changes from normal were observed in any of the parameters measured. Hence, unlike the small bowel, the colon is refractory to the influences of a new environment.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Issue number1
StatePublished - Dec 1984


  • Ileum
  • Intestinal mucosa
  • Transposition
  • Transverse colon

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


Dive into the research topics of 'Morphological effects of transposing a segment of transverse colon into the ileum of the Holtzman rat'. Together they form a unique fingerprint.

Cite this