Mortality rate in veterans with multiple chronic conditions

Todd A. Lee, Alexandra E. Shields, Christine Vogeli, Teresa B. Gibson, Min Woong-Sohn, William D. Marder, David Blumenthal, Kevin B. Weiss

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


BACKGROUND: Among patients with multiple chronic conditions, there is increasing appreciation of the complex interrelatedness of diseases. Previous studies have focused on the prevalence and economic burden associated with multiple chronic conditions, much less is known about the mortality rate associated with specific combinations of multiple diseases. OBJECTIVE: Measure the mortality rate in combinations of 11 chronic conditions. DESIGN: Cohort study of veteran health care users. PARTICIPANTS: Veterans between 55 and 64 years that used Veterans Health Administration health care services between October 1999 and September 2000. MEASUREMENTS: Patients were identified as having one or more of the following: COPD, diabetes, hypertension, rheumatoid arthritis, osteoarthritis, asthma, depression, ischemic heart disease, dementia, stroke, and cancer. Mutually exclusive combinations of disease based on these conditions were created, and 5-year mortality rates were determined. RESULTS: There were 741,847 persons included. The number in each group by a count of conditions was: none = 217,944 (29.34%); 1 = 221,111 (29.8%); 2 = 175,228 (23.6%); 3 = 86,447 (11.7%); and 4+ = 41,117 (5.5%). The 5-year mortality rate by the number of conditions was: none = 4.1%; 1 = 6.0%; 2 = 7.8%; 3 = 11.2%; 4+ = 16.7%. Among combinations with the same number of conditions, there was significant variability in mortality rates. CONCLUSIONS: Patients with multiple chronic conditions have higher mortality rates. Because there was significant variation in mortality across clusters with the same number of conditions, when studying patients with multiple coexisting illnesses, it is important to understand not only that several conditions may be present but that specific conditions can differentially impact the risk of mortality.

Original languageEnglish
Pages (from-to)403-407
Number of pages5
JournalJournal of General Internal Medicine
Issue numberSUPPL. 3
StatePublished - Dec 2007

Bibliographical note

Funding Information:
Acknowledgments: This research was supported in part by grant no. IIR 03-307 from the Department of Veterans Affairs Health Services Research and Development.


  • Chronic conditions
  • Coexistant conditions
  • Mortality
  • Veterans

ASJC Scopus subject areas

  • Internal Medicine


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