Motor and cognitive function evaluation following experimental traumatic brain injury

Scott T. Fujimoto, Luca Longhi, Kathryn E. Saatman, Tracy K. McIntosh

Research output: Contribution to journalReview articlepeer-review

221 Citations (SciVal)

Abstract

Traumatic brain injury (TBI) in humans may cause extensive sensorimotor and cognitive dysfunction. As a result, many TBI researchers are beginning to assess behavioral correlates of histologically determined damage in animal models. Although this is an important step in TBI research, there is a need for standardization between laboratories. The ability to reliably test treatments across laboratories and multiple injury models will close the gap between treatment success in the lab and success in the clinic. The goal of this review is to describe and evaluate the tests employed to assess functional outcome after TBI and to overview aspects of cognitive, sensory, and motor function that may be suitable targets for therapeutic intervention.

Original languageEnglish
Pages (from-to)365-378
Number of pages14
JournalNeuroscience and Biobehavioral Reviews
Volume28
Issue number4
DOIs
StatePublished - Jul 2004

Bibliographical note

Funding Information:
The authors' work was supported by NIH Grants NS4 and NS08803, VA-DOD and VA Merit Review Grants. We would like to thank Jeanne Marks for her help in the preparation of this manuscript.

Keywords

  • Behavior
  • Cognition
  • Mice
  • Rats
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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