Motor and cognitive function evaluation following experimental traumatic brain injury

Scott T. Fujimoto; Luca Longhi; Kathryn E. Saatman; Tracy K. McIntosh

doi:10.1016/j.neubiorev.2004.06.002

Motor and cognitive function evaluation following experimental traumatic brain injury

Scott T. Fujimoto, Luca Longhi, Kathryn E. Saatman, Tracy K. McIntosh

Research output: Contribution to journal › Review article › peer-review

228 Scopus citations

Abstract

Traumatic brain injury (TBI) in humans may cause extensive sensorimotor and cognitive dysfunction. As a result, many TBI researchers are beginning to assess behavioral correlates of histologically determined damage in animal models. Although this is an important step in TBI research, there is a need for standardization between laboratories. The ability to reliably test treatments across laboratories and multiple injury models will close the gap between treatment success in the lab and success in the clinic. The goal of this review is to describe and evaluate the tests employed to assess functional outcome after TBI and to overview aspects of cognitive, sensory, and motor function that may be suitable targets for therapeutic intervention.

Original language	English
Pages (from-to)	365-378
Number of pages	14
Journal	Neuroscience and Biobehavioral Reviews
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.neubiorev.2004.06.002
State	Published - Jul 2004

Bibliographical note

Funding Information:
The authors' work was supported by NIH Grants NS4 and NS08803, VA-DOD and VA Merit Review Grants. We would like to thank Jeanne Marks for her help in the preparation of this manuscript.

Keywords

Behavior
Cognition
Mice
Rats
Traumatic brain injury

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Behavioral Neuroscience

Access to Document

10.1016/j.neubiorev.2004.06.002

Cite this

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title = "Motor and cognitive function evaluation following experimental traumatic brain injury",

abstract = "Traumatic brain injury (TBI) in humans may cause extensive sensorimotor and cognitive dysfunction. As a result, many TBI researchers are beginning to assess behavioral correlates of histologically determined damage in animal models. Although this is an important step in TBI research, there is a need for standardization between laboratories. The ability to reliably test treatments across laboratories and multiple injury models will close the gap between treatment success in the lab and success in the clinic. The goal of this review is to describe and evaluate the tests employed to assess functional outcome after TBI and to overview aspects of cognitive, sensory, and motor function that may be suitable targets for therapeutic intervention.",

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AU - Longhi, Luca

AU - Saatman, Kathryn E.

AU - McIntosh, Tracy K.

N1 - Funding Information: The authors' work was supported by NIH Grants NS4 and NS08803, VA-DOD and VA Merit Review Grants. We would like to thank Jeanne Marks for her help in the preparation of this manuscript.

PY - 2004/7

Y1 - 2004/7

N2 - Traumatic brain injury (TBI) in humans may cause extensive sensorimotor and cognitive dysfunction. As a result, many TBI researchers are beginning to assess behavioral correlates of histologically determined damage in animal models. Although this is an important step in TBI research, there is a need for standardization between laboratories. The ability to reliably test treatments across laboratories and multiple injury models will close the gap between treatment success in the lab and success in the clinic. The goal of this review is to describe and evaluate the tests employed to assess functional outcome after TBI and to overview aspects of cognitive, sensory, and motor function that may be suitable targets for therapeutic intervention.

AB - Traumatic brain injury (TBI) in humans may cause extensive sensorimotor and cognitive dysfunction. As a result, many TBI researchers are beginning to assess behavioral correlates of histologically determined damage in animal models. Although this is an important step in TBI research, there is a need for standardization between laboratories. The ability to reliably test treatments across laboratories and multiple injury models will close the gap between treatment success in the lab and success in the clinic. The goal of this review is to describe and evaluate the tests employed to assess functional outcome after TBI and to overview aspects of cognitive, sensory, and motor function that may be suitable targets for therapeutic intervention.

KW - Behavior

KW - Cognition

KW - Mice

KW - Rats

KW - Traumatic brain injury

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Motor and cognitive function evaluation following experimental traumatic brain injury

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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