Abstract
Injectable biomaterials are an attractive therapy to attenuate left ventricular (LV) remodeling after myocardial infarction (MI). Although studies have shown that injectable hydrogels improve cardiac structure and function in vivo, temporal changes in infarct material properties after treatment have not been assessed. Emerging imaging and modeling techniques now allow for serial, non-invasive estimation of infarct material properties. Specifically, cine magnetic resonance imaging (MRI) assesses global LV structure and function, late-gadolinium enhancement (LGE) MRI enables visualization of infarcted tissue to quantify infarct expansion, and spatial modulation of magnetization (SPAMM) tagging provides passive wall motion assessment as a measure of tissue strain, which can all be used to evaluate infarct properties when combined with finite element (FE) models. In this work, we investigated the temporal effects of degradable hyaluronic acid (HA) hydrogels on global LV remodeling, infarct thinning and expansion, and infarct stiffness in a porcine infarct model for 12 weeks post-MI using MRI and FE modeling. Hydrogel treatment led to decreased LV volumes, improved ejection fraction, and increased wall thickness when compared to controls. FE model simulations demonstrated that hydrogel therapy increased infarct stiffness for 12 weeks post-MI. Thus, evaluation of myocardial tissue properties through MRI and FE modeling provides insight into the influence of injectable hydrogel therapies on myocardial structure and function post-MI.
Original language | English |
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Pages (from-to) | 65-75 |
Number of pages | 11 |
Journal | Biomaterials |
Volume | 69 |
DOIs | |
State | Published - Nov 1 2015 |
Bibliographical note
Funding Information:The authors would like to acknowledge financial support from the National Institutes of Health ( T32 HL007954 , R01 HL73021 , R01 HL063954 , R01 HL111090 ) and the American Heart Association ( 14BGIA18850020 to JFW, Established Investigator Award to JAB).
Publisher Copyright:
© 2015 Elsevier Ltd.
Keywords
- Finite element analysis
- Hyaluronic acid
- Hydrogel
- Left ventricular remodeling
- Magnetic resonance imaging
- Mechanical properties
ASJC Scopus subject areas
- Bioengineering
- Ceramics and Composites
- Biophysics
- Biomaterials
- Mechanics of Materials