MRI evaluation of injectable hyaluronic acid-based hydrogel therapy to limit ventricular remodeling after myocardial infarction

Shauna M. Dorsey, Jeremy R. McGarvey, Hua Wang, Amir Nikou, Leron Arama, Kevin J. Koomalsingh, Norihiro Kondo, Joseph H. Gorman, James J. Pilla, Robert C. Gorman, Jonathan F. Wenk, Jason A. Burdick

Research output: Contribution to journalArticlepeer-review

89 Scopus citations


Injectable biomaterials are an attractive therapy to attenuate left ventricular (LV) remodeling after myocardial infarction (MI). Although studies have shown that injectable hydrogels improve cardiac structure and function in vivo, temporal changes in infarct material properties after treatment have not been assessed. Emerging imaging and modeling techniques now allow for serial, non-invasive estimation of infarct material properties. Specifically, cine magnetic resonance imaging (MRI) assesses global LV structure and function, late-gadolinium enhancement (LGE) MRI enables visualization of infarcted tissue to quantify infarct expansion, and spatial modulation of magnetization (SPAMM) tagging provides passive wall motion assessment as a measure of tissue strain, which can all be used to evaluate infarct properties when combined with finite element (FE) models. In this work, we investigated the temporal effects of degradable hyaluronic acid (HA) hydrogels on global LV remodeling, infarct thinning and expansion, and infarct stiffness in a porcine infarct model for 12 weeks post-MI using MRI and FE modeling. Hydrogel treatment led to decreased LV volumes, improved ejection fraction, and increased wall thickness when compared to controls. FE model simulations demonstrated that hydrogel therapy increased infarct stiffness for 12 weeks post-MI. Thus, evaluation of myocardial tissue properties through MRI and FE modeling provides insight into the influence of injectable hydrogel therapies on myocardial structure and function post-MI.

Original languageEnglish
Pages (from-to)65-75
Number of pages11
StatePublished - Nov 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Ltd.


  • Finite element analysis
  • Hyaluronic acid
  • Hydrogel
  • Left ventricular remodeling
  • Magnetic resonance imaging
  • Mechanical properties

ASJC Scopus subject areas

  • Mechanics of Materials
  • Ceramics and Composites
  • Bioengineering
  • Biophysics
  • Biomaterials


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