Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses

Madan K. Kharel, Lili Zhu, Tao Liu, Jürgen Rohr

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


A series of gene inactivation and gene recombination experiments involving oxygenase encoding genes of the gilvocarcin and jadomycin biosynthetic pathways showed that the enigmatic oxidative rearrangement cascades in these pathways is catalyzed by multi-oxygenase complexes and follows almost identical paths up through the C-C bond cleavage reaction. The two pathways branch beyond this key reaction and end up eventually in the unique tetracyclic benzo[d]naphtho[1,2-b]pyran-6-one and pentacyclic benz[b]oxazolophenanthridine backbones, respectively, typical for these groups of anticancer antibiotics.

Original languageEnglish
Pages (from-to)3780-3781
Number of pages2
JournalJournal of the American Chemical Society
Issue number13
StatePublished - Apr 4 2007

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry
  • Biochemistry
  • Colloid and Surface Chemistry


Dive into the research topics of 'Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses'. Together they form a unique fingerprint.

Cite this