Multi-Scale Modeling of PLGA Microparticle Drug Delivery Systems

Ashlee N. Ford, Daniel W. Pack, Richard D. Braatz

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A mechanistic reaction-diffusion model is proposed for the simulation of drug delivery from PLGA microspheres. The model considers the effects of autocatalytic hydrolysis kinetics and the evolution of the pore network on microsphere-size-dependent drug release. Spatial and temporal variations in the intraparticle pH and the void fraction are reported.

Original languageEnglish
Pages (from-to)1475-1479
Number of pages5
JournalComputer Aided Chemical Engineering
Volume29
DOIs
StatePublished - 2011

Bibliographical note

Funding Information:
Support is acknowledged from the Department of Energy CSGF (Grant #DE-FG02-97ER25308), the National Institutes of Health (NIBIB 5RO1EB005181), and the National Science Foundation (Grant #0426328).

Keywords

  • Biomedical engineering
  • Drug delivery
  • Multi-scale modeling
  • PLGA microspheres
  • Polymer degradation

ASJC Scopus subject areas

  • Chemical Engineering (all)
  • Computer Science Applications

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