Multi-Scale Modeling of PLGA Microparticle Drug Delivery Systems

Ashlee N. Ford; Daniel W. Pack; Richard D. Braatz

doi:10.1016/B978-0-444-54298-4.50074-X

Multi-Scale Modeling of PLGA Microparticle Drug Delivery Systems

Ashlee N. Ford
, Daniel W. Pack
, Richard D. Braatz

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A mechanistic reaction-diffusion model is proposed for the simulation of drug delivery from PLGA microspheres. The model considers the effects of autocatalytic hydrolysis kinetics and the evolution of the pore network on microsphere-size-dependent drug release. Spatial and temporal variations in the intraparticle pH and the void fraction are reported.

Original language	English
Pages (from-to)	1475-1479
Number of pages	5
Journal	Computer Aided Chemical Engineering
Volume	29
DOIs	https://doi.org/10.1016/B978-0-444-54298-4.50074-X
State	Published - 2011

Bibliographical note

Funding Information:
Support is acknowledged from the Department of Energy CSGF (Grant #DE-FG02-97ER25308), the National Institutes of Health (NIBIB 5RO1EB005181), and the National Science Foundation (Grant #0426328).

Funding

Support is acknowledged from the Department of Energy CSGF (Grant #DE-FG02-97ER25308), the National Institutes of Health (NIBIB 5RO1EB005181), and the National Science Foundation (Grant #0426328).

Funders	Funder number
Department of Energy CSGF	-FG02-97ER25308
U.S. Department of Energy Chinese Academy of Sciences Guangzhou Municipal Science and Technology Project Oak Ridge National Laboratory Extreme Science and Engineering Discovery Environment National Science Foundation National Energy Research Scientific Computing Center National Natural Science Foundation of China	0426328
U.S. Department of Energy Chinese Academy of Sciences Guangzhou Municipal Science and Technology Project Oak Ridge National Laboratory Extreme Science and Engineering Discovery Environment National Science Foundation National Energy Research Scientific Computing Center National Natural Science Foundation of China
National Institutes of Health (NIH)
National Institute of Biomedical Imaging and Bioengineering	5RO1EB005181
National Institute of Biomedical Imaging and Bioengineering

Keywords

Biomedical engineering
Drug delivery
Multi-scale modeling
PLGA microspheres
Polymer degradation

ASJC Scopus subject areas

General Chemical Engineering
Computer Science Applications

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10.1016/B978-0-444-54298-4.50074-X

Cite this

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title = "Multi-Scale Modeling of PLGA Microparticle Drug Delivery Systems",

abstract = "A mechanistic reaction-diffusion model is proposed for the simulation of drug delivery from PLGA microspheres. The model considers the effects of autocatalytic hydrolysis kinetics and the evolution of the pore network on microsphere-size-dependent drug release. Spatial and temporal variations in the intraparticle pH and the void fraction are reported.",

keywords = "Biomedical engineering, Drug delivery, Multi-scale modeling, PLGA microspheres, Polymer degradation",

author = "Ford, \{Ashlee N.\} and Pack, \{Daniel W.\} and Braatz, \{Richard D.\}",

note = "Funding Information: Support is acknowledged from the Department of Energy CSGF (Grant \#DE-FG02-97ER25308), the National Institutes of Health (NIBIB 5RO1EB005181), and the National Science Foundation (Grant \#0426328).",

year = "2011",

doi = "10.1016/B978-0-444-54298-4.50074-X",

language = "English",

volume = "29",

pages = "1475--1479",

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T1 - Multi-Scale Modeling of PLGA Microparticle Drug Delivery Systems

AU - Ford, Ashlee N.

AU - Pack, Daniel W.

AU - Braatz, Richard D.

N1 - Funding Information: Support is acknowledged from the Department of Energy CSGF (Grant #DE-FG02-97ER25308), the National Institutes of Health (NIBIB 5RO1EB005181), and the National Science Foundation (Grant #0426328).

PY - 2011

Y1 - 2011

N2 - A mechanistic reaction-diffusion model is proposed for the simulation of drug delivery from PLGA microspheres. The model considers the effects of autocatalytic hydrolysis kinetics and the evolution of the pore network on microsphere-size-dependent drug release. Spatial and temporal variations in the intraparticle pH and the void fraction are reported.

AB - A mechanistic reaction-diffusion model is proposed for the simulation of drug delivery from PLGA microspheres. The model considers the effects of autocatalytic hydrolysis kinetics and the evolution of the pore network on microsphere-size-dependent drug release. Spatial and temporal variations in the intraparticle pH and the void fraction are reported.

KW - Biomedical engineering

KW - Drug delivery

KW - Multi-scale modeling

KW - PLGA microspheres

KW - Polymer degradation

UR - https://www.scopus.com/pages/publications/79958852623

UR - https://www.scopus.com/pages/publications/79958852623#tab=citedBy

U2 - 10.1016/B978-0-444-54298-4.50074-X

DO - 10.1016/B978-0-444-54298-4.50074-X

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AN - SCOPUS:79958852623

SN - 1570-7946

VL - 29

SP - 1475

EP - 1479

JO - Computer Aided Chemical Engineering

JF - Computer Aided Chemical Engineering

ER -

Multi-Scale Modeling of PLGA Microparticle Drug Delivery Systems

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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