Abstract
INTRODUCTION: Video-based cognitive testing is becoming more common. The ‘VCog’ study aims to evaluate the validity, feasibility, and acceptability of a standardized video-administered cognitive research battery. METHODS: Twelve Alzheimer's Disease Research Centers (ADRCs) administered, in randomized order, an in-person and video-adapted Uniform Data Set Version 3 (UDSv3) cognitive assessment battery to participants with normal cognition (n = 156), mild cognitive impairment (MCI; n = 230), and dementia (n = 77). Acceptability of technology and participant experience completing video testing was assessed. RESULTS: Of 463 participants (mean age 75.1 years, 52.5% female, and 25.5% non-White individuals), most rated video testing as easy (90.0%), convenient (95.3%) and would accept it in future visits (75.5%). Greater cognitive impairment was associated with more difficulty with setup and use of video. Staff rated most administrations as producing valid data (94.8%). DISCUSSION: Video-based research cognitive testing with an adapted UDSv3 battery is feasible and well-accepted among older adults with and without cognitive impairment. Highlights: The COVID-19 pandemic increased the need for video-administered cognitive assessments in Alzheimer's Disease Research Centers (ADRCs). Feasibility, acceptability, and validity of video cognitive testing were evaluated. Participant experience and examiner evaluations of data validity were positive. Video assessment may extend the ADRCs reach to otherwise unreachable participants.
| Original language | English |
|---|---|
| Article number | e70842 |
| Journal | Alzheimer's and Dementia |
| Volume | 21 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2025 |
Bibliographical note
Publisher Copyright:© 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Funding
The authors would like to acknowledge the ADRC participants who made all of this work possible.The authors also acknowledge the contributions of VCog Study staff at Wake Forest (Eric Fischer, John Hepler, Marilyn Williams, and Amelia Rhodes) and at participating sites. Lastly, the authors acknowledge the support and guidance of Lisa Barnes, Ph.D. and Hiroko Dodge, Ph.D. This study was funded by R01 AG075959 (MPI Bonnie Sachs, PhD, Stephen Rapp, PhD) and involved the participation of twelve different ADRCs and NACC. Participating NIA-funded ADRCs included: P30 AG066514 (PI Mary Sano, PhD), P30 AG072972 (PI Charles DeCarli, MD), P30 AG072976 (PI Andrew Saykin, PsyD), P30 AG072947 (PI Suzanne Craft, PhD), P30 AG062715 (PI Sanjay Asthana, MD, FRCP), P30 AG072931 (PI Henry Paulson, MD, PhD), P30 AG066509 (PI Thomas Grabowski, MD), P30 AG066518 (PI Lisa Silbert, MD, MCR), P30 AG072946 (PI Linda Van Eldik, PhD), P30 AG062421 (PI Bradley Hyman, MD, PhD), P30 AG072979 (PI David Wolk, MD), P30 AG066511 (PI Allan Levey, MD, PhD). The National Alzheimer's Coordinating Center (NACC) is funded by NIA/NIH Grant U24 AG072122. Dawn Mechanic-Hamilton, PhD reports funding from K23-AG065499. The authors would like to acknowledge the ADRC participants who made all of this work possible.The authors also acknowledge the contributions of VCog Study staff at Wake Forest (Eric Fischer, John Hepler, Marilyn Williams, and Amelia Rhodes) and at participating sites. Lastly, the authors acknowledge the support and guidance of Lisa Barnes, Ph.D. and Hiroko Dodge, Ph.D. This study was funded by R01 AG075959 (MPI Bonnie Sachs, PhD, Stephen Rapp, PhD) and involved the participation of twelve different ADRCs and NACC. Participating NIA‐funded ADRCs included: P30 AG066514 (PI Mary Sano, PhD), P30 AG072972 (PI Charles DeCarli, MD), P30 AG072976 (PI Andrew Saykin, PsyD), P30 AG072947 (PI Suzanne Craft, PhD), P30 AG062715 (PI Sanjay Asthana, MD, FRCP), P30 AG072931 (PI Henry Paulson, MD, PhD), P30 AG066509 (PI Thomas Grabowski, MD), P30 AG066518 (PI Lisa Silbert, MD, MCR), P30 AG072946 (PI Linda Van Eldik, PhD), P30 AG062421 (PI Bradley Hyman, MD, PhD), P30 AG072979 (PI David Wolk, MD), P30 AG066511 (PI Allan Levey, MD, PhD). The National Alzheimer's Coordinating Center (NACC) is funded by NIA/NIH Grant U24 AG072122. Dawn Mechanic‐Hamilton, PhD reports funding from K23‐AG065499.
| Funders | Funder number |
|---|---|
| Alzheimer's Disease Research Center, University of Pittsburgh | |
| National Institute on Aging | |
| National Alzheimer's Coordinating Center | P30 AG072931, P30 AG072976, P30 AG072972, P30 AG062421, P30 AG066511, P30 AG066514, P30 AG066518, P30 AG072946, P30 AG072979, P30 AG062715, P30 AG072947, P30 AG066509 |
| Amelia Rhodes | R01 AG075959 |
| National Institutes of Health (NIH) | U24 AG072122, K23-AG065499 |
Keywords
- Alzheimer's Disease Research Center
- Alzheimer's disease (AD)
- dementia
- mild cognitive impairment
- remote assessment
- telemedicine
- teleneuropsychology
- video assessment
ASJC Scopus subject areas
- Epidemiology
- Health Policy
- Developmental Neuroscience
- Clinical Neurology
- Geriatrics and Gerontology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
