Abstract
Thymine DNA glycosylase (TDG) is a multifunctional protein that plays important roles in DNA repair, DNA demethylation, and transcriptional regulation. These diverse functions make TDG a unique enzyme in embryonic development and carcinogenesis. This review discusses the molecular function of TDG in human cancers and the previously unrecognized value of TDG as a potential target for drug therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 82-89 |
| Number of pages | 8 |
| Journal | Acta Biochimica et Biophysica Sinica |
| Volume | 48 |
| Issue number | 1 |
| DOIs | |
| State | Published - May 27 2015 |
Bibliographical note
Publisher Copyright:© 2015 The Author 2015. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.
Keywords
- DNA demethylation
- DNA repair
- TDG
- cancer
- transcription
ASJC Scopus subject areas
- Molecular Biology
- Biophysics
- Biochemistry
