Multifaceted roles for thymine DNA glycosylase in embryonic development and human carcinogenesis

Xuehe Xu, David S. Watt, Chunming Liu

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations

Abstract

Thymine DNA glycosylase (TDG) is a multifunctional protein that plays important roles in DNA repair, DNA demethylation, and transcriptional regulation. These diverse functions make TDG a unique enzyme in embryonic development and carcinogenesis. This review discusses the molecular function of TDG in human cancers and the previously unrecognized value of TDG as a potential target for drug therapy.

Original languageEnglish
Pages (from-to)82-89
Number of pages8
JournalActa Biochimica et Biophysica Sinica
Volume48
Issue number1
DOIs
StatePublished - May 27 2015

Bibliographical note

Publisher Copyright:
© 2015 The Author 2015. Published by ABBS Editorial Office in association with Oxford University Press on behalf of the Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.

Keywords

  • DNA demethylation
  • DNA repair
  • TDG
  • cancer
  • transcription

ASJC Scopus subject areas

  • Molecular Biology
  • Biophysics
  • Biochemistry

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