Multiformity of induced unifocal ventricular premature beats in human subjects: Electrocardiographic and angiographic correlations.

David C. Booth, Kenneth A. Popio, Leonard S. Gettes

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Single ventricular premature responses induced by strength-interval pacing were elicited at multiple sites in 30 patients undergoing cardiac catheterlzation to determine if and under what circumstances unequivocally unifocal stimulated ventricular premature beats could manifest multiformity of the QRS configuration. Multiformity was defined as unifocal responses whose mean frontal axes differed by greater than 15 ° with or without associated morphologic differences in the horizontal leads. Multiformity occurred in 12 (40 percent) of 30 patients. A statistically significant association was found between multiformity and the presence of a quantitatively defined left ventricular wall motion abnormality (p < 0.01), prior myocardial infarction (p < 0.01) and a left ventricular ejection fraction of less than 0.60 (p < 0.05). Twelve (67 percent) of the 18 patients without multiformity had coronary artery disease, but only 4 of those 12 had a left ventricular wall motion abnormality or prior myocardial infarction, or both. Multiformity was also dependent on the site of stimulation and on the degree of prematurity. The results of this study indicate that the QRS configuration of early premature beats cannot be relied on as a predictor of their site of origin and multiformity is not necesarily synonymous with multifocality.

Original languageEnglish
Pages (from-to)1643-1653
Number of pages11
JournalAmerican Journal of Cardiology
Issue number7
StatePublished - May 1982

Bibliographical note

Funding Information:
From the Division of Cardiology, Department of Medicine, the University of North Carolina School of Medicine, Chapel Hill, North Carolina. This study was supported in part by Grant HL23624 from the National Institutes of Health, Bethesda, Maryland. Manuscript received August 3, 1981; revised manuscript received November 2, 198 1, accepted November 5, 1981. l Present address: Albert B. Chandler Medical Center, Cardiology Division, Department of Medicine, University of Kentucky, Lexington, Kentucky.

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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