Multifunctional nanoparticles for drug delivery and molecular imaging

Gang Bao, Samir Mitragotri, Sheng Tong

Research output: Contribution to journalReview articlepeer-review

391 Scopus citations

Abstract

Recent advances in nanotechnology and growing needs in biomedical applications have driven the development of multifunctional nanoparticles. These nanoparticles, through nanocrystalline synthesis, advanced polymer processing, and coating and functionalization strategies, have the potential to integrate various functionalities, simultaneously providing (a) contrast for different imaging modalities, (b) targeted delivery of drug/gene, and (c) thermal therapies. Although still in its ancy, the field of multifunctional nanoparticles has shown great promise in emerging medical fields such as multimodal imaging, theranostics, and image-guided therapies. In this review, we summarize the techniques used in the synthesis of complex nanostructures, review the major forms of multifunctional nanoparticles that have emerged over the past few years, and provide a perceptual vision of this important field of nanomedicine.

Original languageEnglish
Pages (from-to)253-282
Number of pages30
JournalAnnual Review of Biomedical Engineering
Volume15
DOIs
StatePublished - Jul 2013

Keywords

  • cancer therapy
  • drug delivery
  • inorganic nanoparticle
  • molecular imaging
  • multifunctional nanoparticle

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

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