Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice

S. S. Chung; R. Weindruch; S. R. Schwarze; D. I. McKenzie; Judd M. Aiken

doi:10.1007/BF03324239

Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice

S. S. Chung, R. Weindruch, S. R. Schwarze, D. I. McKenzie, Judd M. Aiken

Health and Clinical Sciences

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57 Scopus citations

Abstract

Multiple mitochondrial DNA (mtDNA) deletions have been associated with aging in humans and monkeys. Since the inbred mouse strain, C57BL/6, has been extensively studied gerontologically, we sought to investigate its utility as a model for examining the importance of mtDNA deletions in aging. Using the polymerase chain reaction (PCR), we analyzed hind limb skeletal muscle from mice of three age groups (5, 16 and 25 months) for the presence of age- associated mtDNA deletions. We observed multiple mtDNA deletions in all three age groups. Further, the number of deletions detected per mouse increased greatly with advancing age. (Aging Clin. Exp. Res. 6: 193–200, 1994)

Original language	English
Pages (from-to)	193-200
Number of pages	8
Journal	Aging clinical and experimental research
Volume	6
Issue number	3
DOIs	https://doi.org/10.1007/BF03324239
State	Published - Jun 1994

Keywords

Aging
DNA deletions
mice mitochondrial

ASJC Scopus subject areas

Aging
Geriatrics and Gerontology

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10.1007/BF03324239

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abstract = "Multiple mitochondrial DNA (mtDNA) deletions have been associated with aging in humans and monkeys. Since the inbred mouse strain, C57BL/6, has been extensively studied gerontologically, we sought to investigate its utility as a model for examining the importance of mtDNA deletions in aging. Using the polymerase chain reaction (PCR), we analyzed hind limb skeletal muscle from mice of three age groups (5, 16 and 25 months) for the presence of age- associated mtDNA deletions. We observed multiple mtDNA deletions in all three age groups. Further, the number of deletions detected per mouse increased greatly with advancing age. (Aging Clin. Exp. Res. 6: 193–200, 1994)",

keywords = "Aging, DNA deletions, mice mitochondrial",

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AU - Weindruch, R.

AU - Schwarze, S. R.

AU - McKenzie, D. I.

AU - Aiken, Judd M.

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N2 - Multiple mitochondrial DNA (mtDNA) deletions have been associated with aging in humans and monkeys. Since the inbred mouse strain, C57BL/6, has been extensively studied gerontologically, we sought to investigate its utility as a model for examining the importance of mtDNA deletions in aging. Using the polymerase chain reaction (PCR), we analyzed hind limb skeletal muscle from mice of three age groups (5, 16 and 25 months) for the presence of age- associated mtDNA deletions. We observed multiple mtDNA deletions in all three age groups. Further, the number of deletions detected per mouse increased greatly with advancing age. (Aging Clin. Exp. Res. 6: 193–200, 1994)

AB - Multiple mitochondrial DNA (mtDNA) deletions have been associated with aging in humans and monkeys. Since the inbred mouse strain, C57BL/6, has been extensively studied gerontologically, we sought to investigate its utility as a model for examining the importance of mtDNA deletions in aging. Using the polymerase chain reaction (PCR), we analyzed hind limb skeletal muscle from mice of three age groups (5, 16 and 25 months) for the presence of age- associated mtDNA deletions. We observed multiple mtDNA deletions in all three age groups. Further, the number of deletions detected per mouse increased greatly with advancing age. (Aging Clin. Exp. Res. 6: 193–200, 1994)

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KW - DNA deletions

KW - mice mitochondrial

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Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice

Abstract

Keywords

ASJC Scopus subject areas

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