Multiple age-associated mitochondrial DNA deletions in skeletal muscle of mice

S. S. Chung, R. Weindruch, S. R. Schwarze, D. I. McKenzie, Judd M. Aiken

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Multiple mitochondrial DNA (mtDNA) deletions have been associated with aging in humans and monkeys. Since the inbred mouse strain, C57BL/6, has been extensively studied gerontologically, we sought to investigate its utility as a model for examining the importance of mtDNA deletions in aging. Using the polymerase chain reaction (PCR), we analyzed hind limb skeletal muscle from mice of three age groups (5, 16 and 25 months) for the presence of age- associated mtDNA deletions. We observed multiple mtDNA deletions in all three age groups. Further, the number of deletions detected per mouse increased greatly with advancing age. (Aging Clin. Exp. Res. 6: 193–200, 1994)

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalAging clinical and experimental research
Volume6
Issue number3
DOIs
StatePublished - Jun 1994

Keywords

  • Aging
  • DNA deletions
  • mice mitochondrial

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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