Multiple estrogen receptor subtypes influence ingestive behavior in female rodents

Jessica Santollo, Derek Daniels

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Postmenopausal women are at an increased risk of obesity and cardiovascular-related diseases. This is attributable, at least in part, to loss of the ovarian hormone estradiol, which inhibits food and fluid intake in humans and laboratory animal models. Although the hypophagic and anti-dipsogenic effects of estradiol have been well documented for decades, the precise mechanisms underlying these effects are not fully understood. An obvious step toward addressing this open question is identifying which estrogen receptor subtypes are involved and what intracellular processes are involved. This question, however, is complicated not only by the variety of estrogen receptor subtypes that exist, but also because many subtypes have multiple locations of action (i.e. in the nucleus or in the plasma membrane). This review will highlight our current understanding of the roles that specific estrogen receptor subtypes play in mediating estradiol's anorexigenic and anti-dipsogenic effects along with highlighting the many open questions that remain. This review will also describe recent work being performed by our laboratory aimed at answering these open questions.

Original languageEnglish
Pages (from-to)431-437
Number of pages7
JournalPhysiology and Behavior
StatePublished - Dec 1 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc.


  • Estradiol
  • Food intake
  • Saline intake
  • Water intake

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


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