Multiple gene products are produced from a novel protein kinase transcription region

D. Martin Watterson, Mark Collinge, Thomas J. Lukas, Linda J. Van Eldik, Konstantin G. Birukov, Olga V. Stepanova, Vladimir P. Shirinsky

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

The nonmuscle/smooth muscle myosin light chain kinase (MLCK) and the kinase related protein (KRP) that lacks protein kinase activity are myosin II binding proteins encoded in the vertebrate genome by a true gene within a gene relationship. The genomic organization and expression result in the same amino acid sequence in different molecular contexts from two different sizes of mRNA. We report here the identification and characterization of a third size class of gene products. The protein appears to be a higher molecular weight form of MLCK with additional amino terminal tail sequence which might provide differential subcellular targeting characteristics.

Original languageEnglish
Pages (from-to)217-220
Number of pages4
JournalFEBS Letters
Volume373
Issue number3
DOIs
StatePublished - Oct 16 1995

Bibliographical note

Funding Information:
Acknowledgements: This work was supported in part by NIH Grant GM 30861 and HHMI Award 75195-546901.

Keywords

  • Amino acid sequence
  • Calmodulin
  • Gene expression
  • Myosin
  • Protein kinase

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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