Multiple regulatory mechanisms control B-1 B cell activation

Vishal J. Sindhava, Subbarao Bondada

Research output: Contribution to journalShort surveypeer-review

46 Scopus citations


B-1 cells constitute a unique subset of B cells identified in several species including mice and humans. B-1 cells are further subdivided into B-1a and B-1b subsets as the former but not the later express CD5.The B-1a subset contributes to innate type of immune responses while the B-1b B cell subset contributes to adaptive responses. B-1 cell responses to B cell receptor (BCR) as well as Toll-like receptor (TLR) ligation are tightly regulated due to the cross-reactivity of antigen specific receptors on B-1 cells to self-antigens. B-1 cells are elevated in several autoimmune diseases. CD5 plays a major role in down regulation of BCR responses in the B-1a cell subset. Reduced amplification of BCR induced signals via CD19 and autoregulation of BCR and TLR responses by B-1 cell produced IL-10 appear to have a role in regulation of both B-1a and B-1b B cell responses. Siglec G receptors and Lyn kinase also regulate B-1 cell responses but their differential role in the two B-1 cell subsets is unknown.

Original languageEnglish
Article numberArticle 372
JournalFrontiers in Immunology
Issue numberDEC
StatePublished - 2012


  • B cell receptor
  • B lymphocyte
  • B-1 cell
  • CD19
  • CD5
  • IL-10
  • SHP-1
  • Toll-like receptor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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