Multiregion comprehensive genomic profiling of a gastric mixed neuroendocrine-nonneuroendocrine neoplasm with trilineage differentiation

Faheem Farooq, Kevin Zarrabi, Keith Sweeney, Joseph Kim, Jela Bandovic, Chiraag Patel, Minsig Choi

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Mixed neuroendocrine-nonneuroendocrine neoplasms (MiNENs) are a group of rare tumors previously known as mixed adenoneuroendocrine carcinomas (MANECs). The neuroendocrine component is high-grade and may consist of small-cell carcinoma or large-cell neuroendocrine carcinoma. The nonneuroendocrine component may consist of adenocarcinoma or squamous cell carcinoma. We report a unique case of a MiNEN with trilineage differentiation: large-cell neuroendocrine carcinoma, squamous cell carcinoma, and adenocarcinoma. The reported patient presented with symptoms of an upper gastrointestinal bleed and was ultimately diagnosed with a MiNEN with trilineage differentiation. This is the first report of this exceedingly rare tumor type to include next-generation sequencing of the 3 separate tumor entities. In addition, we review the current literature and discuss the role of next-generation sequencing in classifying and treating MiNEN tumors.

Original languageEnglish
Pages (from-to)200-207
Number of pages8
JournalJournal of Gastric Cancer
Volume18
Issue number2
DOIs
StatePublished - Jun 2018

Bibliographical note

Publisher Copyright:
© 2018. Korean Gastric Cancer Association.

Keywords

  • Gastric cancer
  • Neuroendocrine neoplasm
  • Precision medicine

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Cancer Research

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