Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease

Thomas J. Montine; Sarah E. Monsell; Thomas G. Beach; Eileen H. Bigio; Yunqi Bu; Nigel J. Cairns; Matthew Frosch; Jonathan Henriksen; Julia Kofler; Walter A. Kukull; Edward B. Lee; Peter T. Nelson; Aimee M. Schantz; Julie A. Schneider; Joshua A. Sonnen; John Q. Trojanowski; Harry V. Vinters; Xiao Hua Zhou; Bradley T. Hyman

doi:10.1016/j.jalz.2015.07.492

Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease

Thomas J. Montine
, Sarah E. Monsell
, Thomas G. Beach
, Eileen H. Bigio
, Yunqi Bu
, Nigel J. Cairns
, Matthew Frosch
, Jonathan Henriksen
, Julia Kofler
, Walter A. Kukull
, Edward B. Lee
, Peter T. Nelson
, Aimee M. Schantz
, Julie A. Schneider
, Joshua A. Sonnen
, John Q. Trojanowski
, Harry V. Vinters
, Xiao Hua Zhou
, Bradley T. Hyman

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Abstract

Introduction Neuropathologic assessment is the current "gold standard" for evaluating the Alzheimer's disease (AD), but there is no consensus on the methods used. Methods Fifteen unstained slides (8 brain regions) from each of the 14 cases were prepared and distributed to 10 different National Institute on Aging AD Centers for application of usual staining and evaluation following recently revised guidelines for AD neuropathologic change. Results Current practice used in the AD Centers Program achieved robustly excellent agreement for the severity score for AD neuropathologic change (average weighted κ =.88, 95% confidence interval: 0.77-0.95) and good-to-excellent agreement for the three supporting scores. Some improvement was observed with consensus evaluation but not with central staining of slides. Evaluation of glass slides and digitally prepared whole-slide images was comparable. Discussion AD neuropathologic evaluation as performed across AD Centers yields data that have high agreement with potential modifications for modest improvements.

Original language	English
Pages (from-to)	164-169
Number of pages	6
Journal	Alzheimer's and Dementia
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/j.jalz.2015.07.492
State	Published - Feb 1 2016

Bibliographical note

Publisher Copyright:
© 2016 The Alzheimer's Association.

Funding

This work was supported by the following grants from the National Institute on Aging , National Institutes of Health : the, National Alzheimer's Coordinating Center ( U01 AG016976 ), Alzheimer's Disease Centers ( P50 AG05133 , P50 AG05134 , P50 AG05136 , P50 AG05681 , P30 AG10161 , P30 AG10124 , P30 AG13854 , P50 AG16570 , P30 AG19610 , and P30 AG28383 ), and P01 AG03991 . We thank Dr Kathleen Montine for editorial assistance. This work was supported by the following grants from the National Institute on Aging, National Institutes of Health: the, National Alzheimer''s Coordinating Center (U01 AG016976), Alzheimer''s Disease Centers (P50 AG05133, P50 AG05134, P50 AG05136, P50 AG05681, P30 AG10161, P30 AG10124, P30 AG13854, P50 AG16570, P30 AG19610, and P30 AG28383), and P01 AG03991. We thank Dr Kathleen Montine for editorial assistance.

Funders	Funder number
Alzheimer's Disease Centers	P50 AG05133, P30 AG10124, P50 AG16570, P50 AG05134, P30 AG28383, P50 AG05136, P30 AG13854, P30 AG19610, P01 AG03991, P30 AG10161, P50 AG05681
National Alzheimer's Coordinating Center	U01 AG016976
National Institutes of Health (NIH)
National Institute on Aging	P50AG005134, P01AG003991

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alzheimer's disease
Methods
Multisite
Neuropathology
Whole-slide imaging

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

Access to Document

10.1016/j.jalz.2015.07.492

Cite this

Montine, T. J., Monsell, S. E., Beach, T. G., Bigio, E. H., Bu, Y., Cairns, N. J., Frosch, M., Henriksen, J., Kofler, J., Kukull, W. A., Lee, E. B., Nelson, P. T., Schantz, A. M., Schneider, J. A., Sonnen, J. A., Trojanowski, J. Q., Vinters, H. V., Zhou, X. H., & Hyman, B. T. (2016). Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimer's and Dementia, 12(2), 164-169. https://doi.org/10.1016/j.jalz.2015.07.492

@article{67964bc9fdb64fd5a8b1e1dae05d4c91,

title = "Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease",

abstract = "Introduction Neuropathologic assessment is the current {"}gold standard{"} for evaluating the Alzheimer's disease (AD), but there is no consensus on the methods used. Methods Fifteen unstained slides (8 brain regions) from each of the 14 cases were prepared and distributed to 10 different National Institute on Aging AD Centers for application of usual staining and evaluation following recently revised guidelines for AD neuropathologic change. Results Current practice used in the AD Centers Program achieved robustly excellent agreement for the severity score for AD neuropathologic change (average weighted κ =.88, 95\% confidence interval: 0.77-0.95) and good-to-excellent agreement for the three supporting scores. Some improvement was observed with consensus evaluation but not with central staining of slides. Evaluation of glass slides and digitally prepared whole-slide images was comparable. Discussion AD neuropathologic evaluation as performed across AD Centers yields data that have high agreement with potential modifications for modest improvements.",

keywords = "Alzheimer's disease, Methods, Multisite, Neuropathology, Whole-slide imaging",

author = "Montine, \{Thomas J.\} and Monsell, \{Sarah E.\} and Beach, \{Thomas G.\} and Bigio, \{Eileen H.\} and Yunqi Bu and Cairns, \{Nigel J.\} and Matthew Frosch and Jonathan Henriksen and Julia Kofler and Kukull, \{Walter A.\} and Lee, \{Edward B.\} and Nelson, \{Peter T.\} and Schantz, \{Aimee M.\} and Schneider, \{Julie A.\} and Sonnen, \{Joshua A.\} and Trojanowski, \{John Q.\} and Vinters, \{Harry V.\} and Zhou, \{Xiao Hua\} and Hyman, \{Bradley T.\}",

note = "Publisher Copyright: {\textcopyright} 2016 The Alzheimer's Association.",

year = "2016",

month = feb,

day = "1",

doi = "10.1016/j.jalz.2015.07.492",

language = "English",

volume = "12",

pages = "164--169",

number = "2",

}

Montine, TJ, Monsell, SE, Beach, TG, Bigio, EH, Bu, Y, Cairns, NJ, Frosch, M, Henriksen, J, Kofler, J, Kukull, WA, Lee, EB, Nelson, PT, Schantz, AM, Schneider, JA, Sonnen, JA, Trojanowski, JQ, Vinters, HV, Zhou, XH & Hyman, BT 2016, 'Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease', Alzheimer's and Dementia, vol. 12, no. 2, pp. 164-169. https://doi.org/10.1016/j.jalz.2015.07.492

TY - JOUR

T1 - Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease

AU - Montine, Thomas J.

AU - Monsell, Sarah E.

AU - Beach, Thomas G.

AU - Bigio, Eileen H.

AU - Bu, Yunqi

AU - Cairns, Nigel J.

AU - Frosch, Matthew

AU - Henriksen, Jonathan

AU - Kofler, Julia

AU - Kukull, Walter A.

AU - Lee, Edward B.

AU - Nelson, Peter T.

AU - Schantz, Aimee M.

AU - Schneider, Julie A.

AU - Sonnen, Joshua A.

AU - Trojanowski, John Q.

AU - Vinters, Harry V.

AU - Zhou, Xiao Hua

AU - Hyman, Bradley T.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Introduction Neuropathologic assessment is the current "gold standard" for evaluating the Alzheimer's disease (AD), but there is no consensus on the methods used. Methods Fifteen unstained slides (8 brain regions) from each of the 14 cases were prepared and distributed to 10 different National Institute on Aging AD Centers for application of usual staining and evaluation following recently revised guidelines for AD neuropathologic change. Results Current practice used in the AD Centers Program achieved robustly excellent agreement for the severity score for AD neuropathologic change (average weighted κ =.88, 95% confidence interval: 0.77-0.95) and good-to-excellent agreement for the three supporting scores. Some improvement was observed with consensus evaluation but not with central staining of slides. Evaluation of glass slides and digitally prepared whole-slide images was comparable. Discussion AD neuropathologic evaluation as performed across AD Centers yields data that have high agreement with potential modifications for modest improvements.

AB - Introduction Neuropathologic assessment is the current "gold standard" for evaluating the Alzheimer's disease (AD), but there is no consensus on the methods used. Methods Fifteen unstained slides (8 brain regions) from each of the 14 cases were prepared and distributed to 10 different National Institute on Aging AD Centers for application of usual staining and evaluation following recently revised guidelines for AD neuropathologic change. Results Current practice used in the AD Centers Program achieved robustly excellent agreement for the severity score for AD neuropathologic change (average weighted κ =.88, 95% confidence interval: 0.77-0.95) and good-to-excellent agreement for the three supporting scores. Some improvement was observed with consensus evaluation but not with central staining of slides. Evaluation of glass slides and digitally prepared whole-slide images was comparable. Discussion AD neuropathologic evaluation as performed across AD Centers yields data that have high agreement with potential modifications for modest improvements.

KW - Alzheimer's disease

KW - Methods

KW - Multisite

KW - Neuropathology

KW - Whole-slide imaging

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M3 - Article

C2 - 26327235

AN - SCOPUS:84957851029

SN - 1552-5260

VL - 12

SP - 164

EP - 169

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 2

ER -

Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease

Abstract

Bibliographical note

Funding

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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