Multivariate statistical analysis of deformation momenta relating anatomical shape to neuropsychological measures

Nikhil Singh, P. Thomas Fletcher, J. Samuel Preston, Linh Ha, Richard King, J. Stephen Marron, Michael Wiener, Sarang Joshi

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

32 Citations (SciVal)

Abstract

The purpose of this study is to characterize the neuroanatomical variations observed in neurological disorders such as dementia. We do a global statistical analysis of brain anatomy and identify the relevant shape deformation patterns that explain corresponding variations in clinical neuropsychological measures. The motivation is to model the inherent relation between anatomical shape and clinical measures and evaluate its statistical significance. We use Partial Least Squares for the multivariate statistical analysis of the deformation momenta under the Large Deformation Diffeomorphic framework. The statistical methodology extracts pertinent directions in the momenta space and the clinical response space in terms of latent variables. We report the results of this analysis on 313 subjects from the Mild Cognitive Impairment group in the Alzheimer's Disease Neuroimaging Initiative (ADNI).

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention, MICCAI2010 - 13th International Conference, Proceedings
Pages529-537
Number of pages9
EditionPART 3
DOIs
StatePublished - 2010
Event13th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2010 - Beijing, China
Duration: Sep 20 2010Sep 24 2010

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
NumberPART 3
Volume6363 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference13th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2010
Country/TerritoryChina
CityBeijing
Period9/20/109/24/10

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science

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