Murine adult hematopoietic cells produce adult erythrocytes in fetal recipients

Jean Paul Blanchet, Roger A. Fleischman, Beatrice Mintz

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Bone marrow cells from normal adult mice were introduced by microinjection via the placenta into W/Wv genetically anemic fetuses of 11 days' gestation. After birth, erythrocytes were fractionated by fluorescence‐activated cell sorting on the basis of antibody binding to a fetal‐specific antigen (Ft). Lysates of Ft‐positive, i.e., fetal, erythrocytes did not detectably contain hemoglobin of the donor type, as judged from electrophoresis of strain‐specific hemoglobin variants. Thus, adult hematopoietic bone marrow cells did not resume fetal differentiation despite their post‐transplant maturation in a fetal environment.

Original languageEnglish
Pages (from-to)197-205
Number of pages9
JournalDevelopmental Genetics
Issue number3
StatePublished - 1982


  • differentiation
  • erythropoiesis
  • gene switching
  • mouse fetal erythrocyte antigen

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology
  • Cell Biology


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