TY - JOUR
T1 - Murine norovirus infection has no significant effect on adaptive immunity to vaccinia virus or influenza A virus
AU - Hensley, Scott E.
AU - Pinto, Amelia K.
AU - Hickman, Heather D.
AU - Kastenmayer, Robin J.
AU - Bennink, Jack R.
AU - Virgin, Herbert W.
AU - Yewdell, Jonathan W.
PY - 2009/7
Y1 - 2009/7
N2 - Murine norovirus (MNV) is endemic in many research mouse colonies. Although MNV infections are typically asymptomatic in immunocompetent mice, the effects of MNV infection on subsequent experimental viral infections are poorly documented. Here, we infected C57BL/6 mice with MNV and then with either vaccinia virus or influenza A virus. MNV infection had no effect on CD8 + T-cell or antibody responses to secondary viruses or to secondary virus-induced morbidity or mortality. While our findings suggest that MNV has little influence on host immunity in immunocompetent mice, we would urge caution regarding the potential effects of MNV on immune responses to viruses and other pathogens, which must be determined on a system-by-system basis.
AB - Murine norovirus (MNV) is endemic in many research mouse colonies. Although MNV infections are typically asymptomatic in immunocompetent mice, the effects of MNV infection on subsequent experimental viral infections are poorly documented. Here, we infected C57BL/6 mice with MNV and then with either vaccinia virus or influenza A virus. MNV infection had no effect on CD8 + T-cell or antibody responses to secondary viruses or to secondary virus-induced morbidity or mortality. While our findings suggest that MNV has little influence on host immunity in immunocompetent mice, we would urge caution regarding the potential effects of MNV on immune responses to viruses and other pathogens, which must be determined on a system-by-system basis.
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U2 - 10.1128/JVI.00623-09
DO - 10.1128/JVI.00623-09
M3 - Article
C2 - 19403665
AN - SCOPUS:67650395616
SN - 0022-538X
VL - 83
SP - 7357
EP - 7360
JO - Journal of Virology
JF - Journal of Virology
IS - 14
ER -