Muscle Fiber Splitting Is a Physiological Response to Extreme Loading in Animals

Kevin A. Murach, Cory M. Dungan, Charlotte A. Peterson, John J. McCarthy

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Skeletal muscle fiber branching and splitting typically is associated with damage and regeneration and is considered pathological when observed during loading-induced hypertrophy. We hypothesize that fiber splitting is a nonpathological component of extreme loading and hypertrophy, which is primarily supported by evidence in animals, and propose that the mechanisms and consequences of fiber splitting deserve further exploration.

Original languageEnglish
Pages (from-to)108-115
Number of pages8
JournalExercise and Sport Sciences Reviews
Volume47
Issue number2
DOIs
StatePublished - Apr 1 2019

Bibliographical note

Publisher Copyright:
© Lippincott Williams & Wilkins.

Keywords

  • Pax7-DTA
  • fiber branching
  • hyperplasia
  • regeneration
  • satellite cells

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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