Skeletal muscle fiber branching and splitting typically is associated with damage and regeneration and is considered pathological when observed during loading-induced hypertrophy. We hypothesize that fiber splitting is a nonpathological component of extreme loading and hypertrophy, which is primarily supported by evidence in animals, and propose that the mechanisms and consequences of fiber splitting deserve further exploration.
|Number of pages||8|
|Journal||Exercise and Sport Sciences Reviews|
|State||Published - Apr 1 2019|
Bibliographical noteFunding Information:
The authors thank Dr. Tim Butterfield for his thoughtful and insightful comments on skeletalmuscle architecture, as well as for providing valuable references. NIH AR071753 to K.A.M. and AR60701 to C.A.P. and J.J.M.
© Lippincott Williams & Wilkins.
- fiber branching
- satellite cells
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation