Muscle Fiber Splitting Is a Physiological Response to Extreme Loading in Animals

Kevin A. Murach, Cory M. Dungan, Charlotte A. Peterson, John J. McCarthy

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Skeletal muscle fiber branching and splitting typically is associated with damage and regeneration and is considered pathological when observed during loading-induced hypertrophy. We hypothesize that fiber splitting is a nonpathological component of extreme loading and hypertrophy, which is primarily supported by evidence in animals, and propose that the mechanisms and consequences of fiber splitting deserve further exploration.

Original languageEnglish
Pages (from-to)108-115
Number of pages8
JournalExercise and Sport Sciences Reviews
Issue number2
StatePublished - Apr 1 2019

Bibliographical note

Funding Information:
The authors thank Dr. Tim Butterfield for his thoughtful and insightful comments on skeletalmuscle architecture, as well as for providing valuable references. NIH AR071753 to K.A.M. and AR60701 to C.A.P. and J.J.M.

Publisher Copyright:
© Lippincott Williams & Wilkins.


  • Pax7-DTA
  • fiber branching
  • hyperplasia
  • regeneration
  • satellite cells

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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