Muscle Fiber Splitting Is a Physiological Response to Extreme Loading in Animals

Kevin A. Murach; Cory M. Dungan; Charlotte A. Peterson; John J. McCarthy

doi:10.1249/JES.0000000000000181

Muscle Fiber Splitting Is a Physiological Response to Extreme Loading in Animals

Kevin A. Murach, Cory M. Dungan, Charlotte A. Peterson, John J. McCarthy

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Skeletal muscle fiber branching and splitting typically is associated with damage and regeneration and is considered pathological when observed during loading-induced hypertrophy. We hypothesize that fiber splitting is a nonpathological component of extreme loading and hypertrophy, which is primarily supported by evidence in animals, and propose that the mechanisms and consequences of fiber splitting deserve further exploration.

Original language	English
Pages (from-to)	108-115
Number of pages	8
Journal	Exercise and Sport Sciences Reviews
Volume	47
Issue number	2
DOIs	https://doi.org/10.1249/JES.0000000000000181
State	Published - Apr 1 2019

Bibliographical note

Publisher Copyright:
© Lippincott Williams & Wilkins.

Keywords

Pax7-DTA
fiber branching
hyperplasia
regeneration
satellite cells

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Physical Therapy, Sports Therapy and Rehabilitation

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10.1249/JES.0000000000000181

Cite this

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title = "Muscle Fiber Splitting Is a Physiological Response to Extreme Loading in Animals",

abstract = "Skeletal muscle fiber branching and splitting typically is associated with damage and regeneration and is considered pathological when observed during loading-induced hypertrophy. We hypothesize that fiber splitting is a nonpathological component of extreme loading and hypertrophy, which is primarily supported by evidence in animals, and propose that the mechanisms and consequences of fiber splitting deserve further exploration.",

keywords = "Pax7-DTA, fiber branching, hyperplasia, regeneration, satellite cells",

author = "Murach, {Kevin A.} and Dungan, {Cory M.} and Peterson, {Charlotte A.} and McCarthy, {John J.}",

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AU - Murach, Kevin A.

AU - Dungan, Cory M.

AU - Peterson, Charlotte A.

AU - McCarthy, John J.

N1 - Publisher Copyright: © Lippincott Williams & Wilkins.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Skeletal muscle fiber branching and splitting typically is associated with damage and regeneration and is considered pathological when observed during loading-induced hypertrophy. We hypothesize that fiber splitting is a nonpathological component of extreme loading and hypertrophy, which is primarily supported by evidence in animals, and propose that the mechanisms and consequences of fiber splitting deserve further exploration.

AB - Skeletal muscle fiber branching and splitting typically is associated with damage and regeneration and is considered pathological when observed during loading-induced hypertrophy. We hypothesize that fiber splitting is a nonpathological component of extreme loading and hypertrophy, which is primarily supported by evidence in animals, and propose that the mechanisms and consequences of fiber splitting deserve further exploration.

KW - Pax7-DTA

KW - fiber branching

KW - hyperplasia

KW - regeneration

KW - satellite cells

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Muscle Fiber Splitting Is a Physiological Response to Extreme Loading in Animals

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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