More than 90% of thyroid cancer belongs to the papillary and follicular thyroid carcinomas based on pathological subtypes. Papillary and follicular thyroid carcinoma are generally associated with a good prognosis. In contrast, other pathological subtypes such as poorly-differentiated and anaplastic thyroid carcinoma (PDTC and ATC) have a poor clinical outcome with a short life expectancy. To identify the genetic variations and biomarkers that may potentially distinguish the aggressive form of thyroid cancer, we performed a retrospective analysis of the formalin-fixed paraffin-embedded tumor samples from 50 patients who mainly displayed aggressive thyroid cancer using next-generation sequencing of 416 solid tumor-related genes. We adopted extensive bioinformatic analysis to vigorously remove germline single-nucleotide polymorphism and systematic sequencing errors, and report here that mutation in DNMT3A gene was significantly enriched in patients with PDTC or ATC.
|Number of pages||7|
|Journal||Cancer Biology and Therapy|
|State||Published - Mar 4 2019|
Bibliographical noteFunding Information:
This study was funded by grants from National Natural Sciences Foundation of China (81473240, 81773749) to Yi Zhang; National Natural Sciences Foundation of China (81472191) to Shundong Ji; Natural Science Foundation of Jiangsu Province of China (BK20151209) to Cheng Ji; and sponsored by Qing Lan Project to Yi Zhang.
© 2018, © 2018 Taylor & Francis Group, LLC.
- gene mutation
- next-generation sequencing
- thyroid carcinoma
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research