Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

Saeed Daneshmandi; Jee Eun Choi; Qi Yan; Cameron R. MacDonald; Manu Pandey; Mounika Goruganthu; Nathan Roberts; Prashant K. Singh; Richard M. Higashi; Andrew N. Lane; Teresa W.M. Fan; Jianmin Wang; Philip L. McCarthy; Elizabeth A. Repasky; Hemn Mohammadpour

doi:10.1038/s41467-024-47096-9

Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

Saeed Daneshmandi, Jee Eun Choi, Qi Yan, Cameron R. MacDonald, Manu Pandey, Mounika Goruganthu, Nathan Roberts, Prashant K. Singh, Richard M. Higashi, Andrew N. Lane, Teresa W.M. Fan, Jianmin Wang, Philip L. McCarthy, Elizabeth A. Repasky, Hemn Mohammadpour

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Myeloid derived suppressor cells (MDSC) are associated with tumourigenesis and therapy response. Here, the authors show that beta 2-adrenergic receptor activation in MDSC leads to metabolic rewiring which regulates chemotherapy response in preclinical models of blood cancer.

Original language	English
Article number	2803
Journal	Nature Communications
Volume	15
Issue number	1
DOIs	https://doi.org/10.1038/s41467-024-47096-9
State	Published - Dec 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2024.

ASJC Scopus subject areas

General Chemistry
General Biochemistry, Genetics and Molecular Biology
General Physics and Astronomy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41467-024-47096-9

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Daneshmandi, S., Choi, J. E., Yan, Q., MacDonald, C. R., Pandey, M., Goruganthu, M., Roberts, N., Singh, P. K., Higashi, R. M., Lane, A. N., Fan, T. W. M., Wang, J., McCarthy, P. L., Repasky, E. A., & Mohammadpour, H. (2024). Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies. Nature Communications, 15(1), Article 2803. https://doi.org/10.1038/s41467-024-47096-9

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title = "Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies",

abstract = "Myeloid derived suppressor cells (MDSC) are associated with tumourigenesis and therapy response. Here, the authors show that beta 2-adrenergic receptor activation in MDSC leads to metabolic rewiring which regulates chemotherapy response in preclinical models of blood cancer.",

author = "Saeed Daneshmandi and Choi, {Jee Eun} and Qi Yan and MacDonald, {Cameron R.} and Manu Pandey and Mounika Goruganthu and Nathan Roberts and Singh, {Prashant K.} and Higashi, {Richard M.} and Lane, {Andrew N.} and Fan, {Teresa W.M.} and Jianmin Wang and McCarthy, {Philip L.} and Repasky, {Elizabeth A.} and Hemn Mohammadpour",

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doi = "10.1038/s41467-024-47096-9",

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Daneshmandi, S, Choi, JE, Yan, Q, MacDonald, CR, Pandey, M, Goruganthu, M, Roberts, N, Singh, PK, Higashi, RM , Lane, AN , Fan, TWM, Wang, J, McCarthy, PL, Repasky, EA & Mohammadpour, H 2024, 'Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies', Nature Communications, vol. 15, no. 1, 2803. https://doi.org/10.1038/s41467-024-47096-9

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T1 - Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

AU - Daneshmandi, Saeed

AU - Choi, Jee Eun

AU - Yan, Qi

AU - MacDonald, Cameron R.

AU - Pandey, Manu

AU - Goruganthu, Mounika

AU - Roberts, Nathan

AU - Singh, Prashant K.

AU - Higashi, Richard M.

AU - Lane, Andrew N.

AU - Fan, Teresa W.M.

AU - Wang, Jianmin

AU - McCarthy, Philip L.

AU - Repasky, Elizabeth A.

AU - Mohammadpour, Hemn

PY - 2024/12

Y1 - 2024/12

N2 - Myeloid derived suppressor cells (MDSC) are associated with tumourigenesis and therapy response. Here, the authors show that beta 2-adrenergic receptor activation in MDSC leads to metabolic rewiring which regulates chemotherapy response in preclinical models of blood cancer.

AB - Myeloid derived suppressor cells (MDSC) are associated with tumourigenesis and therapy response. Here, the authors show that beta 2-adrenergic receptor activation in MDSC leads to metabolic rewiring which regulates chemotherapy response in preclinical models of blood cancer.

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Myeloid-derived suppressor cell mitochondrial fitness governs chemotherapeutic efficacy in hematologic malignancies

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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