Abstract
Myeloid derived suppressor cells (MDSC) are associated with tumourigenesis and therapy response. Here, the authors show that beta 2-adrenergic receptor activation in MDSC leads to metabolic rewiring which regulates chemotherapy response in preclinical models of blood cancer.
| Original language | English |
|---|---|
| Article number | 2803 |
| Journal | Nature Communications |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| State | Published - Dec 2024 |
Bibliographical note
Publisher Copyright:© The Author(s) 2024.
Funding
The authors thank Jeanne M. Prendergast, Feng Li, Eugene Kononov, Courtney C. Ryan, and Suzanne M. Hess, for technical assistance and support, and the Genomics Shared Resource, Translational Imaging Shared Resource, Comparative Oncology Shared Resources (COSR), and the Flow Cytometry Core Facility for expert support. MS were recorded using the Metabolism Shared Resources at the University of Kentucky supported in part by P30CA177558 (to B.M. Evers). This project is supported by K99 HL155792, R00 HL155792, and Roswell Park Alliance Foundation (to H.M.), R01 CA205246 (to E.R.), F30CA265127 (to C.R.M.), and a donation from Brendan and Elise McCarthy (P.L.M.), and NCI grant P30CA016056.
| Funders | Funder number |
|---|---|
| University of Kentucky | K99 HL155792, R00 HL155792 |
| University of Kentucky | |
| Roswell Park Alliance Foundation | R01 CA205246, F30CA265127 |
| Roswell Park Alliance Foundation | |
| National Childhood Cancer Registry – National Cancer Institute | P30CA016056 |
| National Childhood Cancer Registry – National Cancer Institute |
ASJC Scopus subject areas
- General Chemistry
- General Biochemistry, Genetics and Molecular Biology
- General Physics and Astronomy
