Myocardial recovery following LVAD support

Robert S. George, Emma J. Birks

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The use of left ventricular assist devices (LVADs) has been increasing in patients with end-stage heart failure in order to bridge them to transplantation and these devices are now also being used as "destination therapy". Some of these patients have demonstrated signs of recovery of the native heart and this recovery has been sufficient in some cases to allow explantation of the device and hence a new concept of bridge-to-recovery has been described. The rate of successful recovery leading to device explantation, however, has been only 5%–24% until recently when we showed it to be possible to increase the frequency and durability of myocardial recovery using drug therapy combined with LVAD unloading. This chapter summarises different types of LVADs and describes the clinical implications of myocardial recovery following device implantation, monitoring of myocardial recovery and gives the up-to-date findings of the histological and molecular changes in recovery.

Original languageEnglish
Title of host publicationAdvances in Tissue Engineering
Number of pages28
ISBN (Electronic)9781848161832
StatePublished - Jan 1 2008

Bibliographical note

Publisher Copyright:
© 2008 by Imperial College Press.


  • Bridge to Recovery
  • Bridge to Transplantation
  • Excitation-Contraction Coupling
  • Extracellular Matrix
  • Harefield Bridge-to-Recovery Protocol
  • Left Ventricular Assist Device
  • Metalloproteinases
  • Myocardial Recovery
  • Na/Ca Exchange
  • Quality of Life
  • Remodelling
  • Reverse Remodelling
  • SERCA2a

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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