Abstract
Growing evidence suggests that polyphenols could mitigate type 2 diabetes mellitus (T2DM). The glucose-regulatory effects of protein-bound polyphenols, however, have been rarely studied. In this study, macrogenomic and metabolomic analyses were applied to investigate the modulation of myofibrillar protein-chlorogenic acid (MP-CGA) complexes on T2DM rats from the gut microbiota perspective. Results showed that MP-CGA improved hyperglycemia and hyperlipidemia, decreased intestinal inflammation, and reduced intestinal barrier injury. MP-CGA reconstructed gut microbiota in T2DM rats, elevating the abundance of probiotics Bacteroides, Akkermansia, and Parabacteroides while suppressing opportunistic pathogens Enterococcus and Staphylococcus. MP-CGA significantly elevated the concentrations of intestinal metabolites like butyric acid that positively regulate T2DM and reduced the secondary bile acids contents. Therefore, MP-CGA modulated the gut microbiota and related metabolites to maintain stable blood glucose in T2DM rats, providing new insights into the application of protein-polyphenol complexes in foods.
Original language | English |
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Article number | 135195 |
Journal | Food Chemistry |
Volume | 409 |
DOIs | |
State | Published - May 30 2023 |
Bibliographical note
Funding Information:This work was supported by National Key Research and Development Projects (2019YFE0103800), International Research and Development Program of Sichuan (2021YFH0060, 2021YFH0072) and Sichuan Regional Innovation Cooperation Project (2022YFQ0100).
Publisher Copyright:
© 2022 Elsevier Ltd
Keywords
- Gut microbiota
- Intestinal barrier
- Intestinal metabolites
- Protein-polyphenol complexes
- Type 2 diabetes
ASJC Scopus subject areas
- Analytical Chemistry
- Food Science