Myofibrillar protein-chlorogenic acid complexes ameliorate glucose metabolism via modulating gut microbiota in a type 2 diabetic rat model

Zhiwei Zhou, Dan Wang, Xinyi Xu, Jin Dai, Guangjie Lao, Senlin Zhang, Xiaofang Xu, András Dinnyés, Youling Xiong, Qun Sun

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Growing evidence suggests that polyphenols could mitigate type 2 diabetes mellitus (T2DM). The glucose-regulatory effects of protein-bound polyphenols, however, have been rarely studied. In this study, macrogenomic and metabolomic analyses were applied to investigate the modulation of myofibrillar protein-chlorogenic acid (MP-CGA) complexes on T2DM rats from the gut microbiota perspective. Results showed that MP-CGA improved hyperglycemia and hyperlipidemia, decreased intestinal inflammation, and reduced intestinal barrier injury. MP-CGA reconstructed gut microbiota in T2DM rats, elevating the abundance of probiotics Bacteroides, Akkermansia, and Parabacteroides while suppressing opportunistic pathogens Enterococcus and Staphylococcus. MP-CGA significantly elevated the concentrations of intestinal metabolites like butyric acid that positively regulate T2DM and reduced the secondary bile acids contents. Therefore, MP-CGA modulated the gut microbiota and related metabolites to maintain stable blood glucose in T2DM rats, providing new insights into the application of protein-polyphenol complexes in foods.

Original languageEnglish
Article number135195
JournalFood Chemistry
Volume409
DOIs
StatePublished - May 30 2023

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Ltd

Keywords

  • Gut microbiota
  • Intestinal barrier
  • Intestinal metabolites
  • Protein-polyphenol complexes
  • Type 2 diabetes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Food Science

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