TY - JOUR
T1 - Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in disease
AU - Toepfer, Christopher
AU - Caorsi, Valentina
AU - Kampourakis, Thomas
AU - Sikkel, Markus B.
AU - West, Timothy G.
AU - Leung, Man Ching
AU - Al-Saud, Sara A.
AU - MacLeod, Kenneth T.
AU - Lyon, Alexander R.
AU - Marston, Steven B.
AU - Sellers, James R.
AU - Ferenczi, Michael A.
PY - 2013/5/10
Y1 - 2013/5/10
N2 - Background: Cardiac myosin regulatory light chain (RLC) phosphorylation alters cardiac muscle function. Results: Phosphorylation affects mechanical parameters of cardiac muscle contraction during shortening. Conclusion: Phosphorylation impacts mechanical function of cardiac muscle and is altered during cardiac disease. Significance: Understanding RLC regulation by phosphorylation in cardiac muscle contraction is crucial for understanding changes in disease.
AB - Background: Cardiac myosin regulatory light chain (RLC) phosphorylation alters cardiac muscle function. Results: Phosphorylation affects mechanical parameters of cardiac muscle contraction during shortening. Conclusion: Phosphorylation impacts mechanical function of cardiac muscle and is altered during cardiac disease. Significance: Understanding RLC regulation by phosphorylation in cardiac muscle contraction is crucial for understanding changes in disease.
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U2 - 10.1074/jbc.M113.455444
DO - 10.1074/jbc.M113.455444
M3 - Article
C2 - 23530050
AN - SCOPUS:84877688053
SN - 0021-9258
VL - 288
SP - 13446
EP - 13454
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 19
ER -