N-methyl-D-aspartate receptors and Alzheimer's disease

C. W. Cotman, J. W. Geddes, R. J. Bridges, D. T. Monaghan

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The results of several studies now suggest that the density of N-methyl-D-aspartate (NMDA) receptors is maintained in many Alzheimer's disease (AD) cases, although loss of these receptors can occur in specific regions as a consequence of severe neuronal loss. Recent findings demonstrate that there are at least two subtypes of the NMDA receptor which are allosterically regulated. To determine the status of the NMDA receptor in AD, studies are required which will examine the activation state of the NMDA receptor and the properties of subtypes in relation to neuronal density and structure.

Original languageEnglish
Pages (from-to)603-605
Number of pages3
JournalNeurobiology of Aging
Issue number5
StatePublished - 1989

ASJC Scopus subject areas

  • General Neuroscience
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology


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