NADPH oxidase contributes directly to oxidative stress and apoptosis in nerve growth factor-deprived sympathetic neurons.

S. P. Tammariello, M. T. Quinn, S. Estus

Research output: Contribution to journalArticlepeer-review

188 Scopus citations

Abstract

Reactive oxygen species (ROS) are necessary for programmed cell death (PCD) in neurons, but the underlying ROS-producing enzymes have not been identified. NADPH oxidase produces ROS, although the expression of its five subunits are thought to be restricted largely to non-neuronal cells. Here, we show that NADPH oxidase subunits are present in neurons. Moreover, both an NADPH oxidase inhibitor, diphenyleneiodonium, and NAPDH oxidase genetic deficiency inhibit apoptosis in a classic model of PCD, i.e., NGF-deprived sympathetic neurons. Overall, these results indicate that NADPH oxidase is unexpectedly present in neurons and can contribute to neuronal apoptosis.

Original languageEnglish
Pages (from-to)RC53
JournalJournal of Neuroscience
Volume20
Issue number1
DOIs
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • General Neuroscience

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