Nafion-coated electrodes with high selectivity for CNS electrochemistry

Greg A. Gerhardt, Arvin F. Oke, Geza Nagy, Bita Moghaddam, Ralph N. Adams

Research output: Contribution to journalArticlepeer-review

585 Scopus citations


A major improvement in the selectivity of small graphite electrodes used for in vivo electrochemistry is described. The electrodes are coated with Nafion, a perfluorosulfonated polymer. This coating is practically impermeable to ascorbic acid and anionic biogenic amine metabolites and only slightly responsive to neutral metabolites. Thus it becomes selective for the cationic primary neurotransmitters, dopamine, norepinephrine and 5-hydroxytryptamine. Responses of Nafion-coated and untreated electrodes in vivo are compared.

Original languageEnglish
Pages (from-to)390-395
Number of pages6
JournalBrain Research
Issue number2
StatePublished - Jan 9 1984

Bibliographical note

Funding Information:
We wish to thank C. Martin for his generous gift of soluble Nation and for valuable discussions, We are much indebted to E. Murrill and T. Byerley of Midwest Research Institute for their help and the use of their autoclave equipment, and to M. Rice for important advice. Samples of Nation film were kindly supplied by E.I. du Pont de Nemours Company. This work was supported by NIH Grant NS08740.


  • Nafion-coated electrodes
  • in vivo electrochemistry

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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