Naloxone Attenuates Serum Corticosterone and Augments Serum Glucose Concentrations in Broilers Stimulated with Adrenocorticotropin

E. David Peebles, A. L. Pond, J. R. Thompson, C. D. Mcdaniel, N. M. Cox, M. A. Latour

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The effects of exogenous naloxone and adrenocorticotropin (ACTH) on circulating concentrations of corticosterone and glucose in broilers were determined. Birds were injected i.m. at 0 and 2 h with either saline or naloxone, then i.v. at 2.5 h with either saline or ACTH. Control birds received saline at each injection. Blood samples were taken before the experiment started (0 min) and 30, 60, and 90 min after the last injection. Intramuscular injections of naloxone significantly reduced subsequent ACTH-stimulated increases in serum corticosterone; however, when followed by saline, naloxone elevated corticosterone by 90 min after the final injection of saline. Glucose levels were significantly elevated at 60 min in birds receiving ACTH i.v., but remained elevated through 90 min in birds pretreated with naloxone. Naloxone pretreatment attenuated serum corticosterone but augmented serum glucose concentrations in ACTH-stimulated broilers.

Original languageEnglish
Pages (from-to)511-515
Number of pages5
JournalPoultry Science
Issue number3
StatePublished - Mar 1997

Bibliographical note

Funding Information:
Received for publication July 18, 1996. Accepted for publication November 29, 1996. 1This is Journal Article Number J-8412 from the Mississippi Agricultural and Forestry Experiment Station supported by MIS-2985. 2Use of trade names in this publication does not imply endorsement by Mississippi Agriculture and Forestry Experiment Station of these products, nor similar ones mentioned. 3To whom correspondence should be addressed. 4Current address: Purdue University, Poultry Building, West Lafayette, IN 47907-1026.


  • Adrenocorticotropin
  • Broiler
  • Corticosterone
  • Glucose
  • Naloxone

ASJC Scopus subject areas

  • Animal Science and Zoology


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