National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Bradley T. Hyman, Creighton H. Phelps, Thomas G. Beach, Eileen H. Bigio, Nigel J. Cairns, Maria C. Carrillo, Dennis W. Dickson, Charles Duyckaerts, Matthew P. Frosch, Eliezer Masliah, Suzanne S. Mirra, Peter T. Nelson, Julie A. Schneider, Dietmar Rudolf Thal, Bill Thies, John Q. Trojanowski, Harry V. Vinters, Thomas J. Montine

Research output: Contribution to journalArticlepeer-review

1850 Scopus citations

Abstract

A consensus panel from the United States and Europe was convened recently to update and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's disease (AD) and other diseases of brain that are common in the elderly. The new guidelines recognize the pre-clinical stage of AD, enhance the assessment of AD to include amyloid accumulation as well as neurofibrillary change and neuritic plaques, establish protocols for the neuropathologic assessment of Lewy body disease, vascular brain injury, hippocampal sclerosis, and TDP-43 inclusions, and recommend standard approaches for the workup of cases and their clinico-pathologic correlation.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalAlzheimer's and Dementia
Volume8
Issue number1
DOIs
StatePublished - Jan 2012

Bibliographical note

Funding Information:
Support was provided by the NIH ( AG05134 , AG05136 , AG03991 , AG05681 , AG24904 , AG28383 , AG10161 , AG17917 , AG10124 , AG13854 , AG19610 , NS62684 , AG16570 , AG15819 , AG12435 , AG05131 , AG016976 , and AG18840 ) as well as the AA, Arizona Department of Health Services (contract 211002, Arizona Alzheimer’s Consortium), Deutsche Forschungsgemeinschaft (DFG TH-624-4-1) and Alzheimer Forschung Initiative (AFI #10810), the Nancy and Buster Alvord Endowment, and the Charles and Joanne Knight Alzheimer Research Initiative. The authors extend their deepest thanks to Dr. Heiko Braak, Dr. Kelly Del Tredici, Dr. Nina Silverberg, Dr. Walter Kukull, Dr. Kathleen Montine, Dr. Cerise Elliott, and Ms. Sarah Monsell for their valuable input.

Keywords

  • Alzheimer's disease
  • Consensus guidelines
  • Lewy body disease
  • Neuropathology
  • Vascular brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience
  • Health Policy
  • Developmental Neuroscience
  • Epidemiology

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