National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach

Thomas J. Montine; Creighton H. Phelps; Thomas G. Beach; Eileen H. Bigio; Nigel J. Cairns; Dennis W. Dickson; Charles Duyckaerts; Matthew P. Frosch; Eliezer Masliah; Suzanne S. Mirra; Peter T. Nelson; Julie A. Schneider; Dietmar Rudolf Thal; John Q. Trojanowski; Harry V. Vinters; Bradley T. Hyman

doi:10.1007/s00401-011-0910-3

National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach

Thomas J. Montine
, Creighton H. Phelps
, Thomas G. Beach
, Eileen H. Bigio
, Nigel J. Cairns
, Dennis W. Dickson
, Charles Duyckaerts
, Matthew P. Frosch
, Eliezer Masliah
, Suzanne S. Mirra
, Peter T. Nelson
, Julie A. Schneider
, Dietmar Rudolf Thal
, John Q. Trojanowski
, Harry V. Vinters
, Bradley T. Hyman

Research output: Contribution to journal › Article › peer-review

2414 Citations (SciVal)

Abstract

We present a practical guide for the implementation of recently revised National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease (AD). Major revisions from previous consensus criteria are: (1) recognition that AD neuropathologic changes may occur in the apparent absence of cognitive impairment, (2) an "ABC" score for AD neuropathologic change that incorporates histopathologic assessments of amyloid β deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C), and (3) more detailed approaches for assessing commonly co-morbid conditions such as Lewy body disease, vascular brain injury, hippocampal sclerosis, and TAR DNA binding protein (TDP)-43 immunoreactive inclusions. Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations.

Original language	English
Pages (from-to)	1-11
Number of pages	11
Journal	Acta Neuropathologica
Volume	123
Issue number	1
DOIs	https://doi.org/10.1007/s00401-011-0910-3
State	Published - Jan 2012

Bibliographical note

Funding Information:
Acknowledgments Support was provided by the National Institute on Aging (AG05134, AG05136, AG03991, AG05681, AG24904, AG28383, AG10161, AG17917, AG10124, AG13854, AG19610, NS62684, AG16570, AG15819, AG12435, AG05131, AG016976, AG16570, AG15866 and AG18840) as well as the Alzheimer’s Association, Arizona Department of Health Services (contract 211002, Arizona Alzheimer’s Consortium), Deutsche Forschungsgemeinschaft (DFG TH-624-4-1) and Alzheimer Forschung Initiative (AFI #10810), the Nancy and Buster Alvord Endowment, and the Charles and Joanne Knight Alzheimer Research Initiative. We thank Dr. Joshua Sonnen for providing some photomicrographs. The authors extend their deepest

Funding

Acknowledgments Support was provided by the National Institute on Aging (AG05134, AG05136, AG03991, AG05681, AG24904, AG28383, AG10161, AG17917, AG10124, AG13854, AG19610, NS62684, AG16570, AG15819, AG12435, AG05131, AG016976, AG16570, AG15866 and AG18840) as well as the Alzheimer’s Association, Arizona Department of Health Services (contract 211002, Arizona Alzheimer’s Consortium), Deutsche Forschungsgemeinschaft (DFG TH-624-4-1) and Alzheimer Forschung Initiative (AFI #10810), the Nancy and Buster Alvord Endowment, and the Charles and Joanne Knight Alzheimer Research Initiative. We thank Dr. Joshua Sonnen for providing some photomicrographs. The authors extend their deepest

Funders	Funder number
National Institute on Aging	AG10161, AG24904, AG15866, AG12435, AG13854, NS62684, AG16570, AG19610, AG18840, AG03991, P30AG010124, AG016976, AG05136, AG28383, AG17917, AG05134, AG05131, AG05681, AG15819
National Institute on Aging
Alzheimer's Association
Arizona Department of Health Services	211002
Arizona Department of Health Services
Nancy and Buster Alvord Endowment
Alzheimer Forschung Initiative	10810
Alzheimer Forschung Initiative
Banner Alzheimer’s Institute and Arizona Alzheimer’s Consortium
Deutsche Forschungsgemeinschaft	DFG TH-624-4-1
Deutsche Forschungsgemeinschaft

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1007/s00401-011-0910-3

Cite this

Montine, T. J., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., Nelson, P. T., Schneider, J. A., Thal, D. R., Trojanowski, J. Q., Vinters, H. V., & Hyman, B. T. (2012). National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach. Acta Neuropathologica, 123(1), 1-11. https://doi.org/10.1007/s00401-011-0910-3

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title = "National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach",

abstract = "We present a practical guide for the implementation of recently revised National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease (AD). Major revisions from previous consensus criteria are: (1) recognition that AD neuropathologic changes may occur in the apparent absence of cognitive impairment, (2) an {"}ABC{"} score for AD neuropathologic change that incorporates histopathologic assessments of amyloid β deposits (A), staging of neurofibrillary tangles (B), and scoring of neuritic plaques (C), and (3) more detailed approaches for assessing commonly co-morbid conditions such as Lewy body disease, vascular brain injury, hippocampal sclerosis, and TAR DNA binding protein (TDP)-43 immunoreactive inclusions. Recommendations also are made for the minimum sampling of brain, preferred staining methods with acceptable alternatives, reporting of results, and clinico-pathologic correlations.",

author = "Montine, \{Thomas J.\} and Phelps, \{Creighton H.\} and Beach, \{Thomas G.\} and Bigio, \{Eileen H.\} and Cairns, \{Nigel J.\} and Dickson, \{Dennis W.\} and Charles Duyckaerts and Frosch, \{Matthew P.\} and Eliezer Masliah and Mirra, \{Suzanne S.\} and Nelson, \{Peter T.\} and Schneider, \{Julie A.\} and Thal, \{Dietmar Rudolf\} and Trojanowski, \{John Q.\} and Vinters, \{Harry V.\} and Hyman, \{Bradley T.\}",

note = "Funding Information: Acknowledgments Support was provided by the National Institute on Aging (AG05134, AG05136, AG03991, AG05681, AG24904, AG28383, AG10161, AG17917, AG10124, AG13854, AG19610, NS62684, AG16570, AG15819, AG12435, AG05131, AG016976, AG16570, AG15866 and AG18840) as well as the Alzheimer{\textquoteright}s Association, Arizona Department of Health Services (contract 211002, Arizona Alzheimer{\textquoteright}s Consortium), Deutsche Forschungsgemeinschaft (DFG TH-624-4-1) and Alzheimer Forschung Initiative (AFI \#10810), the Nancy and Buster Alvord Endowment, and the Charles and Joanne Knight Alzheimer Research Initiative. We thank Dr. Joshua Sonnen for providing some photomicrographs. The authors extend their deepest",

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Montine, TJ, Phelps, CH, Beach, TG, Bigio, EH, Cairns, NJ, Dickson, DW, Duyckaerts, C, Frosch, MP, Masliah, E, Mirra, SS, Nelson, PT, Schneider, JA, Thal, DR, Trojanowski, JQ, Vinters, HV & Hyman, BT 2012, 'National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach', Acta Neuropathologica, vol. 123, no. 1, pp. 1-11. https://doi.org/10.1007/s00401-011-0910-3

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AU - Bigio, Eileen H.

AU - Cairns, Nigel J.

AU - Dickson, Dennis W.

AU - Duyckaerts, Charles

AU - Frosch, Matthew P.

AU - Masliah, Eliezer

AU - Mirra, Suzanne S.

AU - Nelson, Peter T.

AU - Schneider, Julie A.

AU - Thal, Dietmar Rudolf

AU - Trojanowski, John Q.

AU - Vinters, Harry V.

AU - Hyman, Bradley T.

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National institute on aging-Alzheimer's association guidelines for the neuropathologic assessment of Alzheimer's disease: A practical approach

Abstract

Bibliographical note

Funding

ASJC Scopus subject areas

Access to Document

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