National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Bradley T. Hyman; Creighton H. Phelps; Thomas G. Beach; Eileen H. Bigio; Nigel J. Cairns; Maria C. Carrillo; Dennis W. Dickson; Charles Duyckaerts; Matthew P. Frosch; Eliezer Masliah; Suzanne S. Mirra; Peter T. Nelson; Julie A. Schneider; Dietmar Rudolf Thal; Bill Thies; John Q. Trojanowski; Harry V. Vinters; Thomas J. Montine

doi:10.1016/j.jalz.2011.10.007

National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Bradley T. Hyman, Creighton H. Phelps, Thomas G. Beach, Eileen H. Bigio, Nigel J. Cairns, Maria C. Carrillo, Dennis W. Dickson, Charles Duyckaerts, Matthew P. Frosch, Eliezer Masliah, Suzanne S. Mirra, Peter T. Nelson, Julie A. Schneider, Dietmar Rudolf Thal, Bill Thies, John Q. Trojanowski, Harry V. Vinters, Thomas J. Montine

Research output: Contribution to journal › Article › peer-review

2214 Scopus citations

Abstract

A consensus panel from the United States and Europe was convened recently to update and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's disease (AD) and other diseases of brain that are common in the elderly. The new guidelines recognize the pre-clinical stage of AD, enhance the assessment of AD to include amyloid accumulation as well as neurofibrillary change and neuritic plaques, establish protocols for the neuropathologic assessment of Lewy body disease, vascular brain injury, hippocampal sclerosis, and TDP-43 inclusions, and recommend standard approaches for the workup of cases and their clinico-pathologic correlation.

Original language	English
Pages (from-to)	1-13
Number of pages	13
Journal	Alzheimer's and Dementia
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/j.jalz.2011.10.007
State	Published - Jan 2012

Bibliographical note

Funding Information:
Support was provided by the NIH ( AG05134 , AG05136 , AG03991 , AG05681 , AG24904 , AG28383 , AG10161 , AG17917 , AG10124 , AG13854 , AG19610 , NS62684 , AG16570 , AG15819 , AG12435 , AG05131 , AG016976 , and AG18840 ) as well as the AA, Arizona Department of Health Services (contract 211002, Arizona Alzheimer’s Consortium), Deutsche Forschungsgemeinschaft (DFG TH-624-4-1) and Alzheimer Forschung Initiative (AFI #10810), the Nancy and Buster Alvord Endowment, and the Charles and Joanne Knight Alzheimer Research Initiative. The authors extend their deepest thanks to Dr. Heiko Braak, Dr. Kelly Del Tredici, Dr. Nina Silverberg, Dr. Walter Kukull, Dr. Kathleen Montine, Dr. Cerise Elliott, and Ms. Sarah Monsell for their valuable input.

Funding

Support was provided by the NIH ( AG05134 , AG05136 , AG03991 , AG05681 , AG24904 , AG28383 , AG10161 , AG17917 , AG10124 , AG13854 , AG19610 , NS62684 , AG16570 , AG15819 , AG12435 , AG05131 , AG016976 , and AG18840 ) as well as the AA, Arizona Department of Health Services (contract 211002, Arizona Alzheimer’s Consortium), Deutsche Forschungsgemeinschaft (DFG TH-624-4-1) and Alzheimer Forschung Initiative (AFI #10810), the Nancy and Buster Alvord Endowment, and the Charles and Joanne Knight Alzheimer Research Initiative. The authors extend their deepest thanks to Dr. Heiko Braak, Dr. Kelly Del Tredici, Dr. Nina Silverberg, Dr. Walter Kukull, Dr. Kathleen Montine, Dr. Cerise Elliott, and Ms. Sarah Monsell for their valuable input.

Funders	Funder number
National Institutes of Health (NIH)	AG10161, AG24904, AG10124, AG13854, NS62684, AG16570, AG19610, AG18840, AG03991, AG016976, AG05136, AG28383, AG17917, 211002, AG05134, AG05131, AG05681, AG15819
National Institutes of Health (NIH)
National Institute on Aging	P01AG012435
National Institute on Aging
Nancy and Buster Alvord Endowment
Alzheimer Forschung Initiative	10810
Alzheimer Forschung Initiative
Banner Alzheimer’s Institute and Arizona Alzheimer’s Consortium
Deutsche Forschungsgemeinschaft	DFG TH-624-4-1
Deutsche Forschungsgemeinschaft

Keywords

Alzheimer's disease
Consensus guidelines
Lewy body disease
Neuropathology
Vascular brain injury

ASJC Scopus subject areas

Clinical Neurology
Geriatrics and Gerontology
Psychiatry and Mental health
Cellular and Molecular Neuroscience
Health Policy
Developmental Neuroscience
Epidemiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jalz.2011.10.007

Cite this

Hyman, B. T., Phelps, C. H., Beach, T. G., Bigio, E. H., Cairns, N. J., Carrillo, M. C., Dickson, D. W., Duyckaerts, C., Frosch, M. P., Masliah, E., Mirra, S. S., Nelson, P. T., Schneider, J. A., Thal, D. R., Thies, B., Trojanowski, J. Q., Vinters, H. V., & Montine, T. J. (2012). National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimer's and Dementia, 8(1), 1-13. https://doi.org/10.1016/j.jalz.2011.10.007

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abstract = "A consensus panel from the United States and Europe was convened recently to update and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's disease (AD) and other diseases of brain that are common in the elderly. The new guidelines recognize the pre-clinical stage of AD, enhance the assessment of AD to include amyloid accumulation as well as neurofibrillary change and neuritic plaques, establish protocols for the neuropathologic assessment of Lewy body disease, vascular brain injury, hippocampal sclerosis, and TDP-43 inclusions, and recommend standard approaches for the workup of cases and their clinico-pathologic correlation.",

keywords = "Alzheimer's disease, Consensus guidelines, Lewy body disease, Neuropathology, Vascular brain injury",

author = "Hyman, \{Bradley T.\} and Phelps, \{Creighton H.\} and Beach, \{Thomas G.\} and Bigio, \{Eileen H.\} and Cairns, \{Nigel J.\} and Carrillo, \{Maria C.\} and Dickson, \{Dennis W.\} and Charles Duyckaerts and Frosch, \{Matthew P.\} and Eliezer Masliah and Mirra, \{Suzanne S.\} and Nelson, \{Peter T.\} and Schneider, \{Julie A.\} and Thal, \{Dietmar Rudolf\} and Bill Thies and Trojanowski, \{John Q.\} and Vinters, \{Harry V.\} and Montine, \{Thomas J.\}",

note = "Funding Information: Support was provided by the NIH ( AG05134 , AG05136 , AG03991 , AG05681 , AG24904 , AG28383 , AG10161 , AG17917 , AG10124 , AG13854 , AG19610 , NS62684 , AG16570 , AG15819 , AG12435 , AG05131 , AG016976 , and AG18840 ) as well as the AA, Arizona Department of Health Services (contract 211002, Arizona Alzheimer{\textquoteright}s Consortium), Deutsche Forschungsgemeinschaft (DFG TH-624-4-1) and Alzheimer Forschung Initiative (AFI \#10810), the Nancy and Buster Alvord Endowment, and the Charles and Joanne Knight Alzheimer Research Initiative. The authors extend their deepest thanks to Dr. Heiko Braak, Dr. Kelly Del Tredici, Dr. Nina Silverberg, Dr. Walter Kukull, Dr. Kathleen Montine, Dr. Cerise Elliott, and Ms. Sarah Monsell for their valuable input.",

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Hyman, BT, Phelps, CH, Beach, TG, Bigio, EH, Cairns, NJ, Carrillo, MC, Dickson, DW, Duyckaerts, C, Frosch, MP, Masliah, E, Mirra, SS, Nelson, PT, Schneider, JA, Thal, DR, Thies, B, Trojanowski, JQ, Vinters, HV & Montine, TJ 2012, 'National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease', Alzheimer's and Dementia, vol. 8, no. 1, pp. 1-13. https://doi.org/10.1016/j.jalz.2011.10.007

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T1 - National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

AU - Hyman, Bradley T.

AU - Phelps, Creighton H.

AU - Beach, Thomas G.

AU - Bigio, Eileen H.

AU - Cairns, Nigel J.

AU - Carrillo, Maria C.

AU - Dickson, Dennis W.

AU - Duyckaerts, Charles

AU - Frosch, Matthew P.

AU - Masliah, Eliezer

AU - Mirra, Suzanne S.

AU - Nelson, Peter T.

AU - Schneider, Julie A.

AU - Thal, Dietmar Rudolf

AU - Thies, Bill

AU - Trojanowski, John Q.

AU - Vinters, Harry V.

AU - Montine, Thomas J.

N1 - Funding Information: Support was provided by the NIH ( AG05134 , AG05136 , AG03991 , AG05681 , AG24904 , AG28383 , AG10161 , AG17917 , AG10124 , AG13854 , AG19610 , NS62684 , AG16570 , AG15819 , AG12435 , AG05131 , AG016976 , and AG18840 ) as well as the AA, Arizona Department of Health Services (contract 211002, Arizona Alzheimer’s Consortium), Deutsche Forschungsgemeinschaft (DFG TH-624-4-1) and Alzheimer Forschung Initiative (AFI #10810), the Nancy and Buster Alvord Endowment, and the Charles and Joanne Knight Alzheimer Research Initiative. The authors extend their deepest thanks to Dr. Heiko Braak, Dr. Kelly Del Tredici, Dr. Nina Silverberg, Dr. Walter Kukull, Dr. Kathleen Montine, Dr. Cerise Elliott, and Ms. Sarah Monsell for their valuable input.

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National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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