Natural genetic diversity as a means to uncover stem cell regulatory pathways

Gary Van Zant, Ying Liang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

11 Scopus citations

Abstract

Natural genetic diversity is a largely untapped reservoir for use in the discovery of stem cell regulatory pathways. Here we explore the means by which phenotypic diversity in mice can lead to the discovery of novel genes affecting stem cell regulation. We use as an example the discovery that latexin is a regulator of the natural size of the hematopoietic stem cell population in mice. The fact that it is a negative regulator of stem cell numbers, and thus served as a brake on stem cell expansion, led us to consider the possibility that it acts as a tumor suppressor. Experimental evidence supporting this hypothesis is reviewed.

Original languageEnglish
Title of host publicationHematopoietic Stem Cells VII
Pages170-177
Number of pages8
DOIs
StatePublished - 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1176
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Congenic mouse models
  • Genetic mapping
  • Latexin
  • QTL analysis
  • Stem cells
  • Tumor suppressor

ASJC Scopus subject areas

  • Neuroscience (all)
  • Biochemistry, Genetics and Molecular Biology (all)
  • History and Philosophy of Science

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