Abstract
Natural killer (NK) cells are cytotoxic lymphocytes that function at the interface of innate and adaptive immunity. NK cells are essential for the defense against viral pathogens and are involved in tumor surveillance, atopic diseases, and many autoimmune/inflammatory disorders. In the following chapter, we provide an overview of NK cell development, activation, and NK cell effector function. We provide a comprehensive clinical overview of NK cell deficiencies including impairment of NK cell development and/or function. Overall, this chapter summarizes NK cell biology and function in both healthy and diseased conditions.
| Original language | English |
|---|---|
| Title of host publication | Encyclopedia of Infection and Immunity |
| Subtitle of host publication | Volumes 1-4 |
| Pages | V1-118-V1-129 |
| Volume | 1 |
| ISBN (Electronic) | 9780323903035 |
| DOIs | |
| State | Published - Jan 1 2022 |
Bibliographical note
Publisher Copyright:© 2022 Elsevier Inc. All rights reserved.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cancer
- Cytotoxicity
- Immune deficiency
- Innate immunity
- Natural killer cells
- Viral infection
ASJC Scopus subject areas
- General Immunology and Microbiology
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