Natural Kills Cells

Roman Deniskin; Lisa Forbes Satter

doi:10.1016/B978-0-12-818731-9.00172-5

Natural Kills Cells

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Natural killer (NK) cells are cytotoxic lymphocytes that function at the interface of innate and adaptive immunity. NK cells are essential for the defense against viral pathogens and are involved in tumor surveillance, atopic diseases, and many autoimmune/inflammatory disorders. In the following chapter, we provide an overview of NK cell development, activation, and NK cell effector function. We provide a comprehensive clinical overview of NK cell deficiencies including impairment of NK cell development and/or function. Overall, this chapter summarizes NK cell biology and function in both healthy and diseased conditions.

Original language	English
Title of host publication	Encyclopedia of Infection and Immunity
Subtitle of host publication	Volumes 1-4
Pages	V1-118-V1-129
Volume	1
ISBN (Electronic)	9780323903035
DOIs	https://doi.org/10.1016/B978-0-12-818731-9.00172-5
State	Published - Jan 1 2022

Bibliographical note

Publisher Copyright:
© 2022 Elsevier Inc. All rights reserved.

Keywords

Cancer
Cytotoxicity
Immune deficiency
Innate immunity
Natural killer cells
Viral infection

ASJC Scopus subject areas

General Immunology and Microbiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-818731-9.00172-5

Cite this

@inbook{3d8919d21df84ed0b6f74b0e4e583c25,

title = "Natural Kills Cells",

abstract = "Natural killer (NK) cells are cytotoxic lymphocytes that function at the interface of innate and adaptive immunity. NK cells are essential for the defense against viral pathogens and are involved in tumor surveillance, atopic diseases, and many autoimmune/inflammatory disorders. In the following chapter, we provide an overview of NK cell development, activation, and NK cell effector function. We provide a comprehensive clinical overview of NK cell deficiencies including impairment of NK cell development and/or function. Overall, this chapter summarizes NK cell biology and function in both healthy and diseased conditions.",

keywords = "Cancer, Cytotoxicity, Immune deficiency, Innate immunity, Natural killer cells, Viral infection",

author = "Roman Deniskin and Satter, \{Lisa Forbes\}",

year = "2022",

month = jan,

day = "1",

doi = "10.1016/B978-0-12-818731-9.00172-5",

language = "English",

isbn = "9780128187319",

volume = "1",

pages = "V1--118--V1--129",

booktitle = "Encyclopedia of Infection and Immunity",

}

TY - CHAP

T1 - Natural Kills Cells

AU - Deniskin, Roman

AU - Satter, Lisa Forbes

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Natural killer (NK) cells are cytotoxic lymphocytes that function at the interface of innate and adaptive immunity. NK cells are essential for the defense against viral pathogens and are involved in tumor surveillance, atopic diseases, and many autoimmune/inflammatory disorders. In the following chapter, we provide an overview of NK cell development, activation, and NK cell effector function. We provide a comprehensive clinical overview of NK cell deficiencies including impairment of NK cell development and/or function. Overall, this chapter summarizes NK cell biology and function in both healthy and diseased conditions.

AB - Natural killer (NK) cells are cytotoxic lymphocytes that function at the interface of innate and adaptive immunity. NK cells are essential for the defense against viral pathogens and are involved in tumor surveillance, atopic diseases, and many autoimmune/inflammatory disorders. In the following chapter, we provide an overview of NK cell development, activation, and NK cell effector function. We provide a comprehensive clinical overview of NK cell deficiencies including impairment of NK cell development and/or function. Overall, this chapter summarizes NK cell biology and function in both healthy and diseased conditions.

KW - Cancer

KW - Cytotoxicity

KW - Immune deficiency

KW - Innate immunity

KW - Natural killer cells

KW - Viral infection

UR - http://www.scopus.com/inward/record.url?scp=85216411520&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85216411520&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-818731-9.00172-5

DO - 10.1016/B978-0-12-818731-9.00172-5

M3 - Chapter

AN - SCOPUS:85216411520

SN - 9780128187319

VL - 1

SP - V1-118-V1-129

BT - Encyclopedia of Infection and Immunity

ER -

Natural Kills Cells

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this