Natural product glycorandomization

Jie Yang; Dirk Hoffmeister; Lesley Liu; Xun Fu; Jon S. Thorson

doi:10.1016/j.bmc.2003.12.046

Natural product glycorandomization

Jie Yang, Dirk Hoffmeister, Lesley Liu, Xun Fu, Jon S. Thorson

Research output: Contribution to journal › Short survey › peer-review

91 Scopus citations

Abstract

Glycorandomization is a chemoenzymatic strategy that overcomes the limitations in natural product derivatization associated with both solely chemistry-based approaches or in vivo engineering. In this article we present the basic strategies for glycorandomization development as a next-generation tool in drug discovery.

Original language	English
Pages (from-to)	1577-1584
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	12
Issue number	7
DOIs	https://doi.org/10.1016/j.bmc.2003.12.046
State	Published - Apr 1 2004

Bibliographical note

Funding Information:
This contribution was supported in part by the National Institutes of Health (GM58196, CA84374 and AI52218). D.H. is research fellow of the Deutsche Forschungsgemeinschaft (DFG)

Keywords

Antibiotics
Enzyme catalysis
Galactokinase
Glycosyltransferase
Natural products
Nucleotidylyltransferase

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmc.2003.12.046

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@article{e7fa7387e3d04af098a29d04ba024ac5,

title = "Natural product glycorandomization",

abstract = "Glycorandomization is a chemoenzymatic strategy that overcomes the limitations in natural product derivatization associated with both solely chemistry-based approaches or in vivo engineering. In this article we present the basic strategies for glycorandomization development as a next-generation tool in drug discovery.",

keywords = "Antibiotics, Enzyme catalysis, Galactokinase, Glycosyltransferase, Natural products, Nucleotidylyltransferase",

author = "Jie Yang and Dirk Hoffmeister and Lesley Liu and Xun Fu and Thorson, {Jon S.}",

note = "Funding Information: This contribution was supported in part by the National Institutes of Health (GM58196, CA84374 and AI52218). D.H. is research fellow of the Deutsche Forschungsgemeinschaft (DFG) ",

year = "2004",

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doi = "10.1016/j.bmc.2003.12.046",

language = "English",

volume = "12",

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TY - JOUR

T1 - Natural product glycorandomization

AU - Yang, Jie

AU - Hoffmeister, Dirk

AU - Liu, Lesley

AU - Fu, Xun

AU - Thorson, Jon S.

N1 - Funding Information: This contribution was supported in part by the National Institutes of Health (GM58196, CA84374 and AI52218). D.H. is research fellow of the Deutsche Forschungsgemeinschaft (DFG)

PY - 2004/4/1

Y1 - 2004/4/1

N2 - Glycorandomization is a chemoenzymatic strategy that overcomes the limitations in natural product derivatization associated with both solely chemistry-based approaches or in vivo engineering. In this article we present the basic strategies for glycorandomization development as a next-generation tool in drug discovery.

AB - Glycorandomization is a chemoenzymatic strategy that overcomes the limitations in natural product derivatization associated with both solely chemistry-based approaches or in vivo engineering. In this article we present the basic strategies for glycorandomization development as a next-generation tool in drug discovery.

KW - Antibiotics

KW - Enzyme catalysis

KW - Galactokinase

KW - Glycosyltransferase

KW - Natural products

KW - Nucleotidylyltransferase

UR - http://www.scopus.com/inward/record.url?scp=1542611532&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1542611532&partnerID=8YFLogxK

U2 - 10.1016/j.bmc.2003.12.046

DO - 10.1016/j.bmc.2003.12.046

M3 - Short survey

C2 - 15112655

AN - SCOPUS:1542611532

SN - 0968-0896

VL - 12

SP - 1577

EP - 1584

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 7

ER -

Natural product glycorandomization

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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