Natural product glycorandomization

Jie Yang, Dirk Hoffmeister, Lesley Liu, Xun Fu, Jon S. Thorson

Research output: Contribution to journalShort surveypeer-review

90 Scopus citations

Abstract

Glycorandomization is a chemoenzymatic strategy that overcomes the limitations in natural product derivatization associated with both solely chemistry-based approaches or in vivo engineering. In this article we present the basic strategies for glycorandomization development as a next-generation tool in drug discovery.

Original languageEnglish
Pages (from-to)1577-1584
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume12
Issue number7
DOIs
StatePublished - Apr 1 2004

Bibliographical note

Funding Information:
This contribution was supported in part by the National Institutes of Health (GM58196, CA84374 and AI52218). D.H. is research fellow of the Deutsche Forschungsgemeinschaft (DFG)

Keywords

  • Antibiotics
  • Enzyme catalysis
  • Galactokinase
  • Glycosyltransferase
  • Natural products
  • Nucleotidylyltransferase

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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