Nature's inventory of halogenation catalysts: Oxidative strategies predominate

Frédéric H. Vaillancourt, Ellen Yeh, David A. Vosburg, Sylvie Garneau-Tsodikova, Christopher T. Walsh

Research output: Contribution to journalArticlepeer-review

453 Scopus citations


Halogenated molecules abound in the biosphere. To date, more than 4500 halogenated natural products have been discovered. This paper presents an overview of such molecules. Topics covered are as follows: (1) flourinating enzymes: nonoxidative construction of the C-F bond, (2) oxidative logic in chlorinating, brominating and iodinating enzymes, (3) haloperoxidases, (4) O2-dependent halogenases, (5) cryptic chlorination during cyclopropyl ring construction at unactivated carbons, (6) multiple chlorinations, vinyl halides, and cyclopropanes, (7) other halogenation reactions observed in different classes of enzymes and (8) unifying perspective for oxidative catalysis during biological halogenations.

Original languageEnglish
Pages (from-to)3364-3378
Number of pages15
JournalChemical Reviews
Issue number8
StatePublished - Aug 2006

ASJC Scopus subject areas

  • Chemistry (all)


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