Near-field dynamics of high-speed spray dryer coannular two fluid nozzle: Effects of operational conditions and formulations

Sadegh Poozesh, Stephen W. Grib, Michael W. Renfro, Patrick J. Marsac

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The scaling-up of spray drying processes is an important and challenging step in commercializing specialty products with an ensured quality because it mandates a comprehensive understanding of several steps in the process such as atomization, efficient solvent removal, and particle segregation. The formation of needed particle sizes and shapes is impossible without appropriate atomization through spray dryer nozzles. Hence, research is discussed that investigates the atomization mechanism for a pilot scale externally-mixed, two-fluid nozzle spray dryer by using time resolved particle-image velocimetry to study the behavior of droplets in the near-field of the nozzle tip. Important near-field dynamics of droplets emanating from the nozzle are described, and particle formation characteristics are discussed for several formulations which are widely used in the pharmaceutical industry. Spray angle, droplet breakup length, and droplet sizes and velocity distributions are characterized. Understanding these parameters assists the interpretation of particle formation and enables the modeling of the spray drying process.

Original languageEnglish
Pages (from-to)439-448
Number of pages10
JournalPowder Technology
Volume333
DOIs
StatePublished - Jun 15 2018

Bibliographical note

Publisher Copyright:
© 2017

Keywords

  • Atomization
  • Co-axial two-fluid nozzle
  • High speed imaging
  • Non-dimensional parameters
  • Particle image velocimetry
  • Spray drying process

ASJC Scopus subject areas

  • General Chemical Engineering

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