Abstract
The scaling-up of spray drying processes is an important and challenging step in commercializing specialty products with an ensured quality because it mandates a comprehensive understanding of several steps in the process such as atomization, efficient solvent removal, and particle segregation. The formation of needed particle sizes and shapes is impossible without appropriate atomization through spray dryer nozzles. Hence, research is discussed that investigates the atomization mechanism for a pilot scale externally-mixed, two-fluid nozzle spray dryer by using time resolved particle-image velocimetry to study the behavior of droplets in the near-field of the nozzle tip. Important near-field dynamics of droplets emanating from the nozzle are described, and particle formation characteristics are discussed for several formulations which are widely used in the pharmaceutical industry. Spray angle, droplet breakup length, and droplet sizes and velocity distributions are characterized. Understanding these parameters assists the interpretation of particle formation and enables the modeling of the spray drying process.
Original language | English |
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Pages (from-to) | 439-448 |
Number of pages | 10 |
Journal | Powder Technology |
Volume | 333 |
DOIs | |
State | Published - Jun 15 2018 |
Bibliographical note
Funding Information:We are grateful to the National Institute for Pharmaceutical Technology and Education (NIPTE) and the U.S. Food and Drug Administration (FDA) for providing funds for this research. This study was funded by the FDA Grant to NIPTE titled “CRITICAL PROCESS PARAMETERS FOR SPRAY DRYING PHARMACEUTICALS”; with grant number of U01FD004275 . Appendix A Table 2 Experimental parameters. The nozzle geometry was the same for all experiments. Table 2 Liquid type v g (m/s) v l (m/s) Liquid type v g (m/s) v l (m/s) Water 75 1.3 Methanol-PVP-VA 75 1.3 1.7 1.7 2.6 2.6 3.5 3.5 100 1.3 100 1.3 1.7 1.7 2.6 2.6 3.5 3.5 120 1.3 120 1.3 1.7 1.7 2.6 2.6 3.5 3.5 175 1.3 175 1.3 1.7 1.7 2.6 2.6 3.5 3.5 Methanol 75 1.3 Methanol-HPMC-AS 75 1.3 1.7 1.7 2.6 2.6 3.5 3.5 100 1.3 100 1.3 1.7 1.7 2.6 2.6 3.5 3.5 120 1.3 120 1.3 1.7 1.7 2.6 2.6 3.5 3.5 175 1.3 175 1.3 1.7 1.7 2.6 2.6 3.5 3.5
Publisher Copyright:
© 2017
Keywords
- Atomization
- Co-axial two-fluid nozzle
- High speed imaging
- Non-dimensional parameters
- Particle image velocimetry
- Spray drying process
ASJC Scopus subject areas
- Chemical Engineering (all)