Near-field dynamics of high-speed spray dryer coannular two fluid nozzle: Effects of operational conditions and formulations

Sadegh Poozesh; Stephen W. Grib; Michael W. Renfro; Patrick J. Marsac

doi:10.1016/j.powtec.2018.04.064

Near-field dynamics of high-speed spray dryer coannular two fluid nozzle: Effects of operational conditions and formulations

Sadegh Poozesh, Stephen W. Grib, Michael W. Renfro, Patrick J. Marsac

Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

The scaling-up of spray drying processes is an important and challenging step in commercializing specialty products with an ensured quality because it mandates a comprehensive understanding of several steps in the process such as atomization, efficient solvent removal, and particle segregation. The formation of needed particle sizes and shapes is impossible without appropriate atomization through spray dryer nozzles. Hence, research is discussed that investigates the atomization mechanism for a pilot scale externally-mixed, two-fluid nozzle spray dryer by using time resolved particle-image velocimetry to study the behavior of droplets in the near-field of the nozzle tip. Important near-field dynamics of droplets emanating from the nozzle are described, and particle formation characteristics are discussed for several formulations which are widely used in the pharmaceutical industry. Spray angle, droplet breakup length, and droplet sizes and velocity distributions are characterized. Understanding these parameters assists the interpretation of particle formation and enables the modeling of the spray drying process.

Original language	English
Pages (from-to)	439-448
Number of pages	10
Journal	Powder Technology
Volume	333
DOIs	https://doi.org/10.1016/j.powtec.2018.04.064
State	Published - Jun 15 2018

Bibliographical note

Funding Information:
We are grateful to the National Institute for Pharmaceutical Technology and Education (NIPTE) and the U.S. Food and Drug Administration (FDA) for providing funds for this research. This study was funded by the FDA Grant to NIPTE titled “CRITICAL PROCESS PARAMETERS FOR SPRAY DRYING PHARMACEUTICALS”; with grant number of U01FD004275 . Appendix A Table 2 Experimental parameters. The nozzle geometry was the same for all experiments. Table 2 Liquid type v g (m/s) v l (m/s) Liquid type v g (m/s) v l (m/s) Water 75 1.3 Methanol-PVP-VA 75 1.3 1.7 1.7 2.6 2.6 3.5 3.5 100 1.3 100 1.3 1.7 1.7 2.6 2.6 3.5 3.5 120 1.3 120 1.3 1.7 1.7 2.6 2.6 3.5 3.5 175 1.3 175 1.3 1.7 1.7 2.6 2.6 3.5 3.5 Methanol 75 1.3 Methanol-HPMC-AS 75 1.3 1.7 1.7 2.6 2.6 3.5 3.5 100 1.3 100 1.3 1.7 1.7 2.6 2.6 3.5 3.5 120 1.3 120 1.3 1.7 1.7 2.6 2.6 3.5 3.5 175 1.3 175 1.3 1.7 1.7 2.6 2.6 3.5 3.5

Publisher Copyright:
© 2017

Keywords

Atomization
Co-axial two-fluid nozzle
High speed imaging
Non-dimensional parameters
Particle image velocimetry
Spray drying process

ASJC Scopus subject areas

Chemical Engineering (all)

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10.1016/j.powtec.2018.04.064

Cite this

@article{ba4edae11c094eb8b06492a71a70fd42,

title = "Near-field dynamics of high-speed spray dryer coannular two fluid nozzle: Effects of operational conditions and formulations",

abstract = "The scaling-up of spray drying processes is an important and challenging step in commercializing specialty products with an ensured quality because it mandates a comprehensive understanding of several steps in the process such as atomization, efficient solvent removal, and particle segregation. The formation of needed particle sizes and shapes is impossible without appropriate atomization through spray dryer nozzles. Hence, research is discussed that investigates the atomization mechanism for a pilot scale externally-mixed, two-fluid nozzle spray dryer by using time resolved particle-image velocimetry to study the behavior of droplets in the near-field of the nozzle tip. Important near-field dynamics of droplets emanating from the nozzle are described, and particle formation characteristics are discussed for several formulations which are widely used in the pharmaceutical industry. Spray angle, droplet breakup length, and droplet sizes and velocity distributions are characterized. Understanding these parameters assists the interpretation of particle formation and enables the modeling of the spray drying process.",

keywords = "Atomization, Co-axial two-fluid nozzle, High speed imaging, Non-dimensional parameters, Particle image velocimetry, Spray drying process",

author = "Sadegh Poozesh and Grib, {Stephen W.} and Renfro, {Michael W.} and Marsac, {Patrick J.}",

note = "Funding Information: We are grateful to the National Institute for Pharmaceutical Technology and Education (NIPTE) and the U.S. Food and Drug Administration (FDA) for providing funds for this research. This study was funded by the FDA Grant to NIPTE titled “CRITICAL PROCESS PARAMETERS FOR SPRAY DRYING PHARMACEUTICALS”; with grant number of U01FD004275 . Appendix A Table 2 Experimental parameters. The nozzle geometry was the same for all experiments. Table 2 Liquid type v g (m/s) v l (m/s) Liquid type v g (m/s) v l (m/s) Water 75 1.3 Methanol-PVP-VA 75 1.3 1.7 1.7 2.6 2.6 3.5 3.5 100 1.3 100 1.3 1.7 1.7 2.6 2.6 3.5 3.5 120 1.3 120 1.3 1.7 1.7 2.6 2.6 3.5 3.5 175 1.3 175 1.3 1.7 1.7 2.6 2.6 3.5 3.5 Methanol 75 1.3 Methanol-HPMC-AS 75 1.3 1.7 1.7 2.6 2.6 3.5 3.5 100 1.3 100 1.3 1.7 1.7 2.6 2.6 3.5 3.5 120 1.3 120 1.3 1.7 1.7 2.6 2.6 3.5 3.5 175 1.3 175 1.3 1.7 1.7 2.6 2.6 3.5 3.5 Publisher Copyright: {\textcopyright} 2017",

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doi = "10.1016/j.powtec.2018.04.064",

language = "English",

volume = "333",

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T1 - Near-field dynamics of high-speed spray dryer coannular two fluid nozzle

T2 - Effects of operational conditions and formulations

AU - Poozesh, Sadegh

AU - Grib, Stephen W.

AU - Renfro, Michael W.

AU - Marsac, Patrick J.

N1 - Funding Information: We are grateful to the National Institute for Pharmaceutical Technology and Education (NIPTE) and the U.S. Food and Drug Administration (FDA) for providing funds for this research. This study was funded by the FDA Grant to NIPTE titled “CRITICAL PROCESS PARAMETERS FOR SPRAY DRYING PHARMACEUTICALS”; with grant number of U01FD004275 . Appendix A Table 2 Experimental parameters. The nozzle geometry was the same for all experiments. Table 2 Liquid type v g (m/s) v l (m/s) Liquid type v g (m/s) v l (m/s) Water 75 1.3 Methanol-PVP-VA 75 1.3 1.7 1.7 2.6 2.6 3.5 3.5 100 1.3 100 1.3 1.7 1.7 2.6 2.6 3.5 3.5 120 1.3 120 1.3 1.7 1.7 2.6 2.6 3.5 3.5 175 1.3 175 1.3 1.7 1.7 2.6 2.6 3.5 3.5 Methanol 75 1.3 Methanol-HPMC-AS 75 1.3 1.7 1.7 2.6 2.6 3.5 3.5 100 1.3 100 1.3 1.7 1.7 2.6 2.6 3.5 3.5 120 1.3 120 1.3 1.7 1.7 2.6 2.6 3.5 3.5 175 1.3 175 1.3 1.7 1.7 2.6 2.6 3.5 3.5 Publisher Copyright: © 2017

PY - 2018/6/15

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N2 - The scaling-up of spray drying processes is an important and challenging step in commercializing specialty products with an ensured quality because it mandates a comprehensive understanding of several steps in the process such as atomization, efficient solvent removal, and particle segregation. The formation of needed particle sizes and shapes is impossible without appropriate atomization through spray dryer nozzles. Hence, research is discussed that investigates the atomization mechanism for a pilot scale externally-mixed, two-fluid nozzle spray dryer by using time resolved particle-image velocimetry to study the behavior of droplets in the near-field of the nozzle tip. Important near-field dynamics of droplets emanating from the nozzle are described, and particle formation characteristics are discussed for several formulations which are widely used in the pharmaceutical industry. Spray angle, droplet breakup length, and droplet sizes and velocity distributions are characterized. Understanding these parameters assists the interpretation of particle formation and enables the modeling of the spray drying process.

AB - The scaling-up of spray drying processes is an important and challenging step in commercializing specialty products with an ensured quality because it mandates a comprehensive understanding of several steps in the process such as atomization, efficient solvent removal, and particle segregation. The formation of needed particle sizes and shapes is impossible without appropriate atomization through spray dryer nozzles. Hence, research is discussed that investigates the atomization mechanism for a pilot scale externally-mixed, two-fluid nozzle spray dryer by using time resolved particle-image velocimetry to study the behavior of droplets in the near-field of the nozzle tip. Important near-field dynamics of droplets emanating from the nozzle are described, and particle formation characteristics are discussed for several formulations which are widely used in the pharmaceutical industry. Spray angle, droplet breakup length, and droplet sizes and velocity distributions are characterized. Understanding these parameters assists the interpretation of particle formation and enables the modeling of the spray drying process.

KW - Atomization

KW - Co-axial two-fluid nozzle

KW - High speed imaging

KW - Non-dimensional parameters

KW - Particle image velocimetry

KW - Spray drying process

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DO - 10.1016/j.powtec.2018.04.064

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EP - 448

ER -

Near-field dynamics of high-speed spray dryer coannular two fluid nozzle: Effects of operational conditions and formulations

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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