Near-infrared spectrometry of abdominal aortic aneurysm in the ApoE-/- mouse

Aaron Urbas, Michael W. Manning, Alan Daugherty, Lisa A. Cassis, Robert A. Lodder

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Abdominal aortic aneurysms (AAAs) occur in 5-7% of people over age 60 in the United States. Early intervention in the disease process could have a significant impact on the incidence of complications and on patient survival, but identifying incipient aneurysms can be difficult. ApoE knockout mice develop AAAs following infusion of angiotensin II (AngII) by osmotic minipump into the subcutaneous space of mice at doses ranging from 500 to 1000 ng kg-1 min-1 for 7-28 days. These mice are used as models of AAA development. This study tested the hypothesis that near-IR spectrometry and PCR can determine AngII dose (SEE = 26 ng kg-1 min-1, SEP = 37 ng kg-1 min-1, r2 = 0.99) and collagen/elastin (C/E) ratio (SEE = 0.38, SEP = 0.39, r2 = 0.85) in mouse aortas.

Original languageEnglish
Pages (from-to)3650-3655
Number of pages6
JournalAnalytical Chemistry
Issue number14
StatePublished - Jul 15 2003

ASJC Scopus subject areas

  • Analytical Chemistry


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