Neoclerodane diterpenes as a novel scaffold for μ opioid receptor ligands

Wayne W. Harding, Kevin Tidgewell, Nathan Byrd, Howard Cobb, Christina M. Dersch, Eduardo R. Butelman, Richard B. Rothman, Thomas E. Prisinzano

Research output: Contribution to journalArticlepeer-review

133 Scopus citations


Structural modification of salvinorin A, the active component of Salvia divinorum, has resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and activity. We report in this study a nonnitrogenous neoclerodane diterpene with μ opioid receptor affinity (13) that is an agonist at μ opioid receptors. This represents the identification of a novel structural class of μ opioid receptor agonists.

Original languageEnglish
Pages (from-to)4765-4771
Number of pages7
JournalJournal of Medicinal Chemistry
Issue number15
StatePublished - Jul 28 2005

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery


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