TY - JOUR
T1 - Neoclerodane diterpenes as a novel scaffold for μ opioid receptor ligands
AU - Harding, Wayne W.
AU - Tidgewell, Kevin
AU - Byrd, Nathan
AU - Cobb, Howard
AU - Dersch, Christina M.
AU - Butelman, Eduardo R.
AU - Rothman, Richard B.
AU - Prisinzano, Thomas E.
PY - 2005/7/28
Y1 - 2005/7/28
N2 - Structural modification of salvinorin A, the active component of Salvia divinorum, has resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and activity. We report in this study a nonnitrogenous neoclerodane diterpene with μ opioid receptor affinity (13) that is an agonist at μ opioid receptors. This represents the identification of a novel structural class of μ opioid receptor agonists.
AB - Structural modification of salvinorin A, the active component of Salvia divinorum, has resulted in the synthesis of novel neoclerodane diterpenes with opioid receptor affinity and activity. We report in this study a nonnitrogenous neoclerodane diterpene with μ opioid receptor affinity (13) that is an agonist at μ opioid receptors. This represents the identification of a novel structural class of μ opioid receptor agonists.
UR - https://www.scopus.com/pages/publications/22744432397
UR - https://www.scopus.com/inward/citedby.url?scp=22744432397&partnerID=8YFLogxK
U2 - 10.1021/jm048963m
DO - 10.1021/jm048963m
M3 - Article
C2 - 16033256
AN - SCOPUS:22744432397
SN - 0022-2623
VL - 48
SP - 4765
EP - 4771
JO - Journal of Medicinal Chemistry
JF - Journal of Medicinal Chemistry
IS - 15
ER -