Abstract
This review focuses upon the development, scope, and utility of the highly versatile chemoselective alkoxyamine-based 'neoglycosylation' reaction first described by Peri and Dumy. The fundamentals of neoglycosylation and the subsequent development of a 'neoglycorandomization' platform to afford differentially-glycosylated libraries of plant-based natural products, microbial-based natural products, and small molecule-based drugs for drug discovery applications are discussed. This journal is
Original language | English |
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Pages (from-to) | 1036-1047 |
Number of pages | 12 |
Journal | MedChemComm |
Volume | 5 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry