Abstract
This review focuses upon the development, scope, and utility of the highly versatile chemoselective alkoxyamine-based 'neoglycosylation' reaction first described by Peri and Dumy. The fundamentals of neoglycosylation and the subsequent development of a 'neoglycorandomization' platform to afford differentially-glycosylated libraries of plant-based natural products, microbial-based natural products, and small molecule-based drugs for drug discovery applications are discussed. This journal is
| Original language | English |
|---|---|
| Pages (from-to) | 1036-1047 |
| Number of pages | 12 |
| Journal | MedChemComm |
| Volume | 5 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2014 |
Funding
| Funders | Funder number |
|---|---|
| National Center for Advancing Translational Sciences (NCATS) | UL1TR000117 |
| National Institutes of Health (NIH) | CA84374, AI52218 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry
Fingerprint
Dive into the research topics of 'Neoglycosylation and neoglycorandomization: Enabling tools for the discovery of novel glycosylated bioactive probes and early stage leads'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver