Neonatal alloimmune thrombocytopenia due to Anti-HPA-1b (PL(A2)) (Zwb)

J. L. Winters, C. D. Jennings, N. S. Desai, L. G. Dickson, R. F. Ford

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background: Neonatal alloimmune thrombocytopenia is a rare condition due to passively acquired maternal antibodies directed against paternal platelet antigens inherited by the infant. Only 5 cases have been reported due to antibodies against HPA-1b (PL(A2)) (Zwb). Case Report: We report a case of neonatal alloimmune thrombocytopenia due to anti-HPA-1b in the second pregnancy of a 26-year-old Caucasian female. The male infant was treated with a 5-day course of intravenous immunoglobulin without complications. We report the HLA phenotype of the infant's mother and summarize the previous case reports due to anti-HPA-1b. Conclusion: Based on this case and a review of the literature, intravenous immunoglobulin as well as random donor exchange transfusion and random donor platelet transfusions are effective in the treatment of neonatal alloimmune thrombocytopenia due to anti-HPA-1b. Obvious associations between HLA alleles and sensitization to HPA-1b have not been elucidated.

Original languageEnglish
Pages (from-to)256-259
Number of pages4
JournalVox Sanguinis
Issue number4
StatePublished - 1998

ASJC Scopus subject areas

  • Hematology


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