Nerve growth factor (NGF) is well known to be involved in the development, survival, and maintenance of sympathetic and neural crest-derived sensory neurons in the peripheral nervous system. Over the last 10-15 years, however, the role of NGF as a necessary trophic substrate for magnocellular cholinergic neurons in the central nervous system (CNS) has emerged. Because the trophic effects of NGF are initiated by its interaction with membrane-bound receptors, the characterization, localization, and function of these specific NGF receptors are essential to understanding the many actions of NGF. The first part of this review will summarize briefly the presence and possible role of NGF in the CNS, with the remainder of the review focusing on what is known about the receptor to NGF.
|Number of pages||12|
|State||Published - Dec 1988|
Bibliographical noteFunding Information:
Preparation of this manuscript was supported by the Center for Neurological Research, Hahnemann University, and a grant from the American Federation for Aging Research. The author is indebted to S. E. Kennedy for critical review of this manuscript, and Dr. M. Fian-data for helpful suggestions.
ASJC Scopus subject areas
- Developmental Neuroscience