Nerve growth factor receptors in the central nervous system

Joe E. Springer

doi:10.1016/0014-4886(88)90231-2

Nerve growth factor receptors in the central nervous system

Joe E. Springer

Research output: Contribution to journal › Review article › peer-review

92 Scopus citations

Abstract

Nerve growth factor (NGF) is well known to be involved in the development, survival, and maintenance of sympathetic and neural crest-derived sensory neurons in the peripheral nervous system. Over the last 10-15 years, however, the role of NGF as a necessary trophic substrate for magnocellular cholinergic neurons in the central nervous system (CNS) has emerged. Because the trophic effects of NGF are initiated by its interaction with membrane-bound receptors, the characterization, localization, and function of these specific NGF receptors are essential to understanding the many actions of NGF. The first part of this review will summarize briefly the presence and possible role of NGF in the CNS, with the remainder of the review focusing on what is known about the receptor to NGF.

Original language	English
Pages (from-to)	354-365
Number of pages	12
Journal	Experimental Neurology
Volume	102
Issue number	3
DOIs	https://doi.org/10.1016/0014-4886(88)90231-2
State	Published - Dec 1988

Bibliographical note

Funding Information:
Preparation of this manuscript was supported by the Center for Neurological Research, Hahnemann University, and a grant from the American Federation for Aging Research. The author is indebted to S. E. Kennedy for critical review of this manuscript, and Dr. M. Fian-data for helpful suggestions.

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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10.1016/0014-4886(88)90231-2

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title = "Nerve growth factor receptors in the central nervous system",

abstract = "Nerve growth factor (NGF) is well known to be involved in the development, survival, and maintenance of sympathetic and neural crest-derived sensory neurons in the peripheral nervous system. Over the last 10-15 years, however, the role of NGF as a necessary trophic substrate for magnocellular cholinergic neurons in the central nervous system (CNS) has emerged. Because the trophic effects of NGF are initiated by its interaction with membrane-bound receptors, the characterization, localization, and function of these specific NGF receptors are essential to understanding the many actions of NGF. The first part of this review will summarize briefly the presence and possible role of NGF in the CNS, with the remainder of the review focusing on what is known about the receptor to NGF.",

author = "Springer, {Joe E.}",

note = "Funding Information: Preparation of this manuscript was supported by the Center for Neurological Research, Hahnemann University, and a grant from the American Federation for Aging Research. The author is indebted to S. E. Kennedy for critical review of this manuscript, and Dr. M. Fian-data for helpful suggestions.",

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N2 - Nerve growth factor (NGF) is well known to be involved in the development, survival, and maintenance of sympathetic and neural crest-derived sensory neurons in the peripheral nervous system. Over the last 10-15 years, however, the role of NGF as a necessary trophic substrate for magnocellular cholinergic neurons in the central nervous system (CNS) has emerged. Because the trophic effects of NGF are initiated by its interaction with membrane-bound receptors, the characterization, localization, and function of these specific NGF receptors are essential to understanding the many actions of NGF. The first part of this review will summarize briefly the presence and possible role of NGF in the CNS, with the remainder of the review focusing on what is known about the receptor to NGF.

AB - Nerve growth factor (NGF) is well known to be involved in the development, survival, and maintenance of sympathetic and neural crest-derived sensory neurons in the peripheral nervous system. Over the last 10-15 years, however, the role of NGF as a necessary trophic substrate for magnocellular cholinergic neurons in the central nervous system (CNS) has emerged. Because the trophic effects of NGF are initiated by its interaction with membrane-bound receptors, the characterization, localization, and function of these specific NGF receptors are essential to understanding the many actions of NGF. The first part of this review will summarize briefly the presence and possible role of NGF in the CNS, with the remainder of the review focusing on what is known about the receptor to NGF.

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JO - Experimental Neurology

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Nerve growth factor receptors in the central nervous system

Abstract

Bibliographical note

ASJC Scopus subject areas

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