Nerve growth factor receptors in the central nervous system

Joe E. Springer

Research output: Contribution to journalReview articlepeer-review

87 Scopus citations


Nerve growth factor (NGF) is well known to be involved in the development, survival, and maintenance of sympathetic and neural crest-derived sensory neurons in the peripheral nervous system. Over the last 10-15 years, however, the role of NGF as a necessary trophic substrate for magnocellular cholinergic neurons in the central nervous system (CNS) has emerged. Because the trophic effects of NGF are initiated by its interaction with membrane-bound receptors, the characterization, localization, and function of these specific NGF receptors are essential to understanding the many actions of NGF. The first part of this review will summarize briefly the presence and possible role of NGF in the CNS, with the remainder of the review focusing on what is known about the receptor to NGF.

Original languageEnglish
Pages (from-to)354-365
Number of pages12
JournalExperimental Neurology
Issue number3
StatePublished - Dec 1988

Bibliographical note

Funding Information:
Preparation of this manuscript was supported by the Center for Neurological Research, Hahnemann University, and a grant from the American Federation for Aging Research. The author is indebted to S. E. Kennedy for critical review of this manuscript, and Dr. M. Fian-data for helpful suggestions.

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience


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