Network interactions mediated by new excitatory connections between CA1 pyramidal cells in rats with kainate-induced epilepsy

Bret N. Smith, F. Edward Dudek

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Axon sprouting and synaptic reorganization in the hippocampus are associated with the development of seizures in temporal lobe epilepsy. Synaptic interactions among CA1 pyramidal cells were examined in fragments of hippocampal slices containing only the CA1 area from saline- and kainate-treated rats. Glutamate microapplication to the pyramidal cell layer increased excitatory postsynaptic current (EPSC) frequency, but only in rats with kainate-induced epilepsy. In bicuculline, action potentials evoked in single pyramidal cells increased the frequency of network bursts only in slices from rats with kainate-induced epilepsy. These data further support the hypothesis that excitatory connections between CA1 pyramidal cells increase after kainate-induced status epilepticus.

Original languageEnglish
Pages (from-to)1655-1658
Number of pages4
JournalJournal of Neurophysiology
Volume87
Issue number3
DOIs
StatePublished - 2002

ASJC Scopus subject areas

  • General Neuroscience
  • Physiology

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