TY - JOUR
T1 - Network interactions mediated by new excitatory connections between CA1 pyramidal cells in rats with kainate-induced epilepsy
AU - Smith, Bret N.
AU - Dudek, F. Edward
PY - 2002
Y1 - 2002
N2 - Axon sprouting and synaptic reorganization in the hippocampus are associated with the development of seizures in temporal lobe epilepsy. Synaptic interactions among CA1 pyramidal cells were examined in fragments of hippocampal slices containing only the CA1 area from saline- and kainate-treated rats. Glutamate microapplication to the pyramidal cell layer increased excitatory postsynaptic current (EPSC) frequency, but only in rats with kainate-induced epilepsy. In bicuculline, action potentials evoked in single pyramidal cells increased the frequency of network bursts only in slices from rats with kainate-induced epilepsy. These data further support the hypothesis that excitatory connections between CA1 pyramidal cells increase after kainate-induced status epilepticus.
AB - Axon sprouting and synaptic reorganization in the hippocampus are associated with the development of seizures in temporal lobe epilepsy. Synaptic interactions among CA1 pyramidal cells were examined in fragments of hippocampal slices containing only the CA1 area from saline- and kainate-treated rats. Glutamate microapplication to the pyramidal cell layer increased excitatory postsynaptic current (EPSC) frequency, but only in rats with kainate-induced epilepsy. In bicuculline, action potentials evoked in single pyramidal cells increased the frequency of network bursts only in slices from rats with kainate-induced epilepsy. These data further support the hypothesis that excitatory connections between CA1 pyramidal cells increase after kainate-induced status epilepticus.
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U2 - 10.1152/jn.00581.2001
DO - 10.1152/jn.00581.2001
M3 - Article
C2 - 11877537
AN - SCOPUS:0036095992
SN - 0022-3077
VL - 87
SP - 1655
EP - 1658
JO - Journal of Neurophysiology
JF - Journal of Neurophysiology
IS - 3
ER -