Neural Precursors as Preferential Targets for Drug Abuse: Long-Term Consequences and Latent Susceptibility to Central Nervous System Disorders

Kurt F. Hauser, Nazira El-Hage, Shreya Buch, Gregory N. Barnes, Henrietta S. Bada, James R. Pauly

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Considerable evidence suggests that drugs with abuse liability disrupt development by affecting the production of new neurons and glia. The effects of drug abuse are not limited to a particular cell type, germinal zone, or stage of development, but rather uniquely affect individual neuronal and glial precursor types with various germinal zones. Germinal zones are targeted to varying degrees by most substance with abuse liability. This chapter discusses the effects of opiates and nicotine on the genesis of neural cells.

Original languageEnglish
Title of host publicationBrain Development
Subtitle of host publicationNormal Processes and the Effects of Alcohol and Nicotine
ISBN (Electronic)9780199865147
DOIs
StatePublished - May 25 2006

Bibliographical note

Publisher Copyright:
© 2006 by Oxford University Press, Inc. All rights reserved.

Keywords

  • Development
  • Drug abuse
  • Germinal zone
  • Neurons
  • Opiates

ASJC Scopus subject areas

  • General Neuroscience

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