Neurobehavioral testing in subarachnoid hemorrhage: A review of methods and current findings in rodents

Nefize Turan, Brandon A. Miller, Robert A. Heider, Maheen Nadeem, Iqbal Sayeed, Donald G. Stein, Gustavo Pradilla

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

The most important aspect of a preclinical study seeking to develop a novel therapy for neurological diseases is whether the therapy produces any clinically relevant functional recovery. For this purpose, neurobehavioral tests are commonly used to evaluate the neuroprotective efficacy of treatments in a wide array of cerebrovascular diseases and neurotrauma. Their use, however, has been limited in experimental subarachnoid hemorrhage studies. After several randomized, double-blinded, controlled clinical trials repeatedly failed to produce a benefit in functional outcome despite some improvement in angiographic vasospasm, more rigorous methods of neurobehavioral testing became critical to provide a more comprehensive evaluation of the functional efficacy of proposed treatments. While several subarachnoid hemorrhage studies have incorporated an array of neurobehavioral assays, a standardized methodology has not been agreed upon. Here, we review neurobehavioral tests for rodents and their potential application to subarachnoid hemorrhage studies. Developing a standardized neurobehavioral testing regimen in rodent studies of subarachnoid hemorrhage would allow for better comparison of results between laboratories and a better prediction of what interventions would produce functional benefits in humans.

Original languageEnglish
Pages (from-to)3461-3474
Number of pages14
JournalJournal of Cerebral Blood Flow and Metabolism
Volume37
Issue number11
DOIs
StatePublished - Nov 1 2017

Bibliographical note

Publisher Copyright:
© 2016, © The Author(s) 2016.

Keywords

  • Animal models
  • behavior (rodent)
  • cognitive impairment
  • experimental
  • subarachnoid hemorrhage

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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